製品の概要

製品の詳細

  • 由来Synthetic
  • アミノ酸配列
    • 生物種Human
    • 配列C-YPDSDVLFRYKVKS
    • 領域493 to 506

関連製品

特性

Our Abpromise guarantee covers the use of ab45557 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Blocking - Blocking peptide for Anti-CYP7B1 antibody (ab19043)

  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

関連情報

  • 別名
    • 25 hydroxycholesterol 7 alpha hydroxylase
    • 25-hydroxycholesterol 7-alpha-hydroxylase
    • CP7B
    • CP7B1_HUMAN
    • Cyp7b1
    • Cytochrome P450 7B1
    • Cytochrome P450 family 7 subfamily B polypeptide 1
    • Cytochrome P450 subfamily VIIB polypeptide 1
    • Oxysterol 7-alpha-hydroxylase
    • Oxysterol 7alpha hydroxylase
    see all
  • 組織特異性Brain, testis, ovary, prostate, liver, colon, kidney, and small intestine.
  • パスウェイLipid metabolism; bile acid biosynthesis.
  • 関連疾患Defects in CYP7B1 are the cause of spastic paraplegia autosomal recessive type 5A (SPG5A) [MIM:270800]. Spastic paraplegia is a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body.
    Defects in CYP7B1 are the cause of congenital bile acid synthesis defect type 3 (CBAS3) [MIM:613812]. Clinical features include severe cholestasis, cirrhosis and liver synthetic failure. Hepatic microsomal oxysterol 7-alpha-hydroxylase activity is undetectable.
  • 配列類似性Belongs to the cytochrome P450 family.
  • 細胞内局在Endoplasmic reticulum membrane. Microsome membrane.
  • Information by UniProt

Human CYP7B1 peptide (ab45557) 使用論文

ab45557 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"