製品の概要

製品の詳細

  • 由来Synthetic
  • アミノ酸配列
    • 生物種Human
    • 配列C-PANSQSRMSTNM
    • 領域480 to 491

関連製品

特性

Our Abpromise guarantee covers the use of ab23045 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Blocking - Blocking peptide for Anti-CSN1 antibody (ab4535)

  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

関連情報

  • 別名
    • COP9 signalosome complex subunit 1
    • COP9 signalosome subunit 1
    • COPS1
    • CSN 1
    • CSN1_HUMAN
    • FUS6/COP11, Arabidopsis, homolog of
    • G protein pathway suppressor 1
    • GPS-1
    • Gps1
    • JAB1-containing signalosome subunit 1
    • Protein GPS1
    • Protein MFH
    • SGN1
    • Signalosome subunit 1
    see all
  • 機能Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein-and mitogen-activated protein kinase-mediated signal transduction.
  • 組織特異性Widely expressed.
  • 配列類似性Belongs to the CSN1 family.
    Contains 1 PCI domain.
  • ドメインThe PCI domain is necessary and sufficient for the interactions with other CSN subunits of the complex. Mediates the interaction with CAPN8.
    The N-terminal part (1-216), which is not required for deneddylating activity and CSN complex formation, is nevertheless essential for other aspects of CSN complex function, such as repression of c-fos/FOS expression.
  • 翻訳後修飾Phosphorylated upon DNA damage, probably by ATM or ATR.
  • 細胞内局在Cytoplasm. Nucleus.
  • Information by UniProt

Human CSN1 peptide (ab23045) 使用論文

ab23045 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab23045.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"