製品の概要

製品の詳細

  • 由来Synthetic
  • アミノ酸配列
    • 生物種Human
    • 配列VHRWPSARVRQTWS
    • 領域206 to 219

関連製品

特性

Our Abpromise guarantee covers the use of ab42263 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Blocking - Blocking peptide for Anti-CCKBR antibody (ab14440)

  • 製品の状態Lyophilised
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. After reconstitution store at -20ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 0.1% Acetic acid

  • 再構成Resuspend in 0.1% acetic acid for required concentration.

関連情報

  • 別名
    • CCK B
    • CCK B receptor
    • CCK BR
    • CCK-B receptor
    • CCK-BR
    • CCK2 R
    • CCK2 receptor
    • CCK2-R
    • CCKB
    • CCKB receptor
    • CCKBR
    • CCKR Type B
    • CCKRB
    • Cholecystokinin 2 receptor
    • Cholecystokinin B receptor
    • Cholecystokinin-2 receptor
    • Cholecystokinin2 receptor
    • CholecystokininB receptor
    • GASR
    • GASR_HUMAN
    • Gastrin receptor
    • Gastrin/cholecystokinin type B receptor
    • Gastrin\cholecystokinin brain receptor
    see all
  • 機能Receptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
    Isoform 2 is constitutively activated and may regulate cancer cell proliferation via a gastrin-independent mechanism.
  • 組織特異性Isoform 1 is expressed in brain, pancreas, stomach, the colon cancer cell line LoVo and the T-lymphoblastoma Jurkat, but not in heart, placenta, liver, lung, skeletal muscle, kidney or the stomach cancer cell line AGS. Expressed at high levels in the small cell lung cancer cell line NCI-H510, at lower levels in NCI-H345, NCI-H69 and GLC28 cell lines, not expressed in GLC19 cell line. Within the stomach, expressed at high levels in the mucosa of the gastric fundus and at low levels in the antrum and duodenum. Isoform 2 is present in pancreatic cancer cells and colorectal cancer cells, but not in normal pancreas or colonic mucosa. Isoform 3 is expressed in brain, pancreas, stomach, the stomach cancer cell line AGS and the colon cancer cell line LoVo.
  • 配列類似性Belongs to the G-protein coupled receptor 1 family.
  • 細胞内局在Cell membrane.
  • Information by UniProt

Human CCKBR peptide (ab42263) 使用論文

ab42263 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"