製品の概要

製品の詳細

  • 由来Synthetic
  • アミノ酸配列
    • アクセッション番号Q92851
    • 生物種Human
    • 配列ISAQTPRPPMRRWSSVS Amino acids 505 to 521 of human caspase-10 (1)
    • 領域505 to 521

関連製品

特性

Our Abpromise guarantee covers the use of ab8377 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Blocking - Blocking peptide for Anti-Caspase-10 antibody (ab2012)

  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    PBS with 0.1% BSA 0.02% sodium azide pH7.2

関連情報

  • 別名
    • ALPS2
    • Apoptotic protease Mch-4
    • CASP 10
    • CASP-10
    • CASP10
    • CASPA_HUMAN
    • Caspase 10 apoptosis related cysteine peptidase
    • Caspase-10 subunit p12
    • FADD like ICE2
    • Fas associated death domain protein
    • FAS-associated death domain protein interleukin-1B-converting enzyme 2
    • FLICE 2
    • FLICE2
    • ICE like apoptotic protease 4
    • ICE-like apoptotic protease 4
    • Interleukin 1B converting enzyme 2
    • MCH 4
    see all
  • 機能Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase-3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-
    -AMC and Asp-Glu-Val-Asp-
    -AMC.
    Isoform C is proteolytically inactive.
  • 組織特異性Detectable in most tissues. Lowest expression is seen in brain, kidney, prostate, testis and colon.
  • 関連疾患Defects in CASP10 are the cause of autoimmune lymphoproliferative syndrome type 2A (ALPS2A) [MIM:603909]. ALPS2 is characterized by abnormal lymphocyte and dendritic cell homeostasis and immune regulatory defects.
    Defects in CASP10 are a cause of familial non-Hodgkin lymphoma (NHL) [MIM:605027]. NHL is a cancer that starts in cells of the lymph system, which is part of the body's immune system. NHLs can occur at any age and are often marked by enlarged lymph nodes, fever and weight loss.
    Defects in CASP10 are a cause of gastric cancer (GASC) [MIM:613659]. A malignant disease which starts in the stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body. The term gastric cancer or gastric carcinoma refers to adenocarcinoma of the stomach that accounts for most of all gastric malignant tumors. Two main histologic types are recognized, diffuse type and intestinal type carcinomas. Diffuse tumors are poorly differentiated infiltrating lesions resulting in thickening of the stomach. In contrast, intestinal tumors are usually exophytic, often ulcerating, and associated with intestinal metaplasia of the stomach, most often observed in sporadic disease.
  • 配列類似性Belongs to the peptidase C14A family.
    Contains 2 DED (death effector) domains.
  • 翻訳後修飾Cleavage by granzyme B and autocatalytic activity generate the two active subunits.
    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Information by UniProt

Human Caspase-10 peptide (ab8377) 使用論文

ab8377 has not yet been referenced specifically in any publications.

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