製品の概要

  • 製品名Human CARD15 peptide

製品の詳細

  • 由来Synthetic
  • アミノ酸配列
    • 生物種Human

関連製品

特性

Our Abpromise guarantee covers the use of ab39813 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Blocking - Blocking peptide for Anti-CARD15 antibody (ab36836)

  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: 0.02% Sodium Azide
    Constituents: 0.1% BSA, PBS, pH 7.2

関連情報

  • 別名
    • ACUG
    • Arthrocutaneouveal granulomatosis
    • BLAU
    • CARD15
    • Caspase recruitment domain family, member 15
    • Caspase recruitment domain protein 15
    • Caspase recruitment domain-containing protein 15
    • CD
    • CLR16.3
    • IBD1
    • Inflammatory bowel disease protein 1
    • LRR containing protein
    • NLR family, CARD domain containing 2
    • NLRC2
    • NOD like receptor C2
    • NOD2
    • NOD2 protein
    • NOD2_HUMAN
    • NOD2B
    • nucleotide binding oligomerization domain 2
    • Nucleotide binding oligomerization domain containing 2
    • Nucleotide binding oligomerization domain, leucine rich repeat and CARD domain containing 2
    • Nucleotide-binding oligomerization domain-containing protein 2
    • PSORAS1
    see all
  • 機能Induces NF-kappa-B via RICK (CARDIAK, RIP2) and IKK-gamma. Confers responsiveness to intracellular bacterial lipopolysaccharides (LPS).
  • 組織特異性Monocytes-specific.
  • 関連疾患Defects in NOD2 are the cause of Blau syndrome (BS) [MIM:186580]. BS is a rare autosomal dominant disorder characterized by early-onset granulomatous arthritis, uveitis and skin rash.
    Defects in NOD2 are a cause of susceptibility to inflammatory bowel disease type 1 (IBD1) [MIM:266600]. IBD1 is a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints.
    Defects in NOD2 are the cause of sarcoidosis early-onset (EOS) [MIM:609464]. EOS is a form of sarcoidosis manifesting in children younger than 4 years of age. Sarcoidosis is an idiopathic, systemic, inflammatory disease characterized by the formation of immune granulomas in involved organs. Granulomas predominantly invade the lungs and the lymphatic system, but also skin, liver, spleen, eyes and other organs may be involved. Early-onset sarcoidosis is quite rare and has a distinct triad of skin, joint and eye disorders, without apparent pulmonary involvement. Compared with an asymptomatic and sometimes naturally disappearing course of the disease in older children, early-onset sarcoidosis is progressive and in many cases causes severe complications, such as blindness, joint destruction and visceral involvement.
  • 配列類似性Contains 2 CARD domains.
    Contains 9 LRR (leucine-rich) repeats.
    Contains 1 NACHT domain.
  • 細胞内局在Cytoplasm.
  • Information by UniProt

Human CARD15 peptide (ab39813) 使用論文

ab39813 has not yet been referenced specifically in any publications.

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