製品の概要

製品の詳細

  • 由来
    Synthetic
  • アミノ酸配列
    • 生物種
      Human

関連製品

特性

Our Abpromise guarantee covers the use of ab39733 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Blocking

    Western blot

  • 製品の状態
    Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: 0.02% Sodium Azide
    Constituents: PBS, 0.1% bovine serum albumin, pH 7.2

関連情報

  • 別名
    • B lymphoma Mo MLV insertion region (mouse)
    • B lymphoma Mo MLV insertion region 1 homolog
    • Bmi 1
    • BMI1
    • BMI1 polycomb ring finger oncogene
    • BMI1_HUMAN
    • Flvi 2/bmi 1
    • FLVI2/BMI1
    • MGC12685
    • Murine leukemia viral (bmi 1) oncogene homolog
    • Oncogene BMI 1
    • PCGF 4
    • PCGF4
    • Polycomb complex protein BMI 1
    • Polycomb complex protein BMI-1
    • Polycomb group protein Bmi1
    • Polycomb group ring finger 4
    • Polycomb group RING finger protein 4
    • RING finger protein 51
    • RNF 51
    • RNF51
    see all
  • 機能
    Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2.
  • 配列類似性
    Contains 1 RING-type zinc finger.
  • 翻訳後修飾
    Monoubiquitinated (By similarity). May be polyubiquitinated; which does not lead to proteasomal degradation.
  • 細胞内局在
    Nucleus. Cytoplasm.
  • Information by UniProt

参考文献

ab39733 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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