Human BCRP/ABCG2 peptide (ab100820)

製品の概要

製品の詳細

  • 由来Synthetic

関連製品

特性

Our Abpromise guarantee covers the use of ab100820 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 精製度70 - 90% by HPLC.

  • 製品の状態Liquid
  • 備考

    - First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
    - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
    - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
    - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
    - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Information available upon request.

関連情報

  • 別名
    • ABC transporter
    • ABC15
    • ABCG 2
    • ABCG2
    • ABCG2_HUMAN
    • ABCP
    • ATP binding cassette sub family G (WHITE) member 2
    • ATP binding cassette transporter G2
    • ATP-binding cassette sub-family G member 2
    • BCRP
    • BCRP1
    • BMDP
    • Breast cancer resistance protein
    • CD338
    • CDw338
    • CDw338 antigen
    • EST157481
    • GOUT1
    • MGC102821
    • Mitoxantrone resistance associated protein
    • Mitoxantrone resistance-associated protein
    • MRX
    • Multi drug resistance efflux transport ATP binding cassette sub family G (WHITE) member 2
    • MXR
    • MXR1
    • Placenta specific ATP binding cassette transporter
    • Placenta specific MDR protein
    • Placenta-specific ATP-binding cassette transporter
    • UAQTL1
    see all
  • 機能Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. May be involved in brain-to-blood efflux. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. When overexpressed, the transfected cells become resistant to mitoxantrone, daunorubicin and doxorubicin, display diminished intracellular accumulation of daunorubicin, and manifest an ATP-dependent increase in the efflux of rhodamine 123.
  • 組織特異性Highly expressed in placenta. Low expression in small intestine, liver and colon.
  • 配列類似性Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
    Contains 1 ABC transmembrane type-2 domain.
    Contains 1 ABC transporter domain.
  • 翻訳後修飾Glycosylation-deficient ABCG2 is normally expressed and functional.
  • 細胞内局在Cell membrane.
  • Information by UniProt

Human BCRP/ABCG2 peptide (ab100820) 使用論文

ab100820 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"