製品の概要

製品の詳細

  • 由来Synthetic
  • アミノ酸配列
    • 生物種Human
    • 配列LSATPLYGNVHSW-C
    • 領域2 to 14

関連製品

特性

Our Abpromise guarantee covers the use of ab23093 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Blocking - Blocking peptide for Anti-BCOR antibody (ab5276)

  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

関連情報

  • 別名
    • 5830466J11Rik
    • 8430401K06Rik
    • ANOP 2
    • ANOP2
    • BCL 6 co repressor
    • BCL 6 corepressor
    • BCL 6 interacting corepressor
    • BCL-6 corepressor
    • BCL6 co repressor
    • BCL6 corepressor
    • BCL6 interacting corepressor
    • BCoR
    • BCOR_HUMAN
    • FLJ20285
    • FLJ38041
    • KIAA1575
    • MAA 2
    • MAA2
    • MCOPS 2
    • MCOPS2
    • MGC131961
    • MGC71031
    see all
  • 機能Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2).
  • 組織特異性Ubiquitously expressed.
  • 関連疾患Defects in BCOR are the cause of microphthalmia syndromic type 2 (MCOPS2) [MIM:300166]. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. MCOPS2 is a very rare multiple congenital anomaly syndrome characterized by eye anomalies (congenital cataract, microphthalmia, or secondary glaucoma), facial abnormalities (long narrow face, high nasal bridge, pointed nose with cartilages separated at the tip, cleft palate, or submucous cleft palate), cardiac anomalies (atrial septal defect, ventricular septal defect, or floppy mitral valve) and dental abnormalities (canine radiculomegaly, delayed dentition, oligodontia, persistent primary teeth, or variable root length).
  • 配列類似性Belongs to the BCOR family.
    Contains 3 ANK repeats.
  • 細胞内局在Nucleus.
  • Information by UniProt

Human BCOR peptide (ab23093) 使用論文

ab23093 has not yet been referenced specifically in any publications.

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