The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Blocking - Blocking peptide for Anti-BCAR3 antibody (ab21705)
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Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Breast cancer anti estrogen resistance 3
Breast cancer anti estrogen resistance protein 3
Breast cancer anti-estrogen resistance protein 3
Breast cancer antiestrogen resistance 3
dJ1033H22.2 breast cancer anti estrogen resistance 3
dJ1033H22.2 breast cancer antiestrogen resistance 3
Novel SH2 containing protein 2
Novel SH2-containing protein 2
SH2 containing protein Nsp2
SH2 domain containing protein 3B
SH2 domain-containing protein 3B
機能May act as an adapter protein and couple activated growth factor receptors to a signaling pathway that regulates the proliferation in breast cancer cells. When overexpressed, it confers anti-estrogen resistance in breast cancer cell lines. May also be regulated by cellular adhesion to extracellular matrix proteins.
組織特異性Ubiquitously expressed. Found in several cancer cell lines, but not in nonmalignant breast tissue.