Angiotensin I Converting Enzyme (peptidyl dipeptidase A) 2
Angiotensin I converting enzyme 2
Angiotensin-converting enzyme homolog
metalloprotease MPROT 15
Processed angiotensin-converting enzyme 2
機能Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses.
組織特異性Expressed in endothelial cells from small and large arteries, and in arterial smooth muscle cells. Expressed in lung alveolar epithelial cells, enterocytes of the small intestine, Leydig cells and Sertoli cells (at protein level). Expressed in heart, kidney, testis, and gastrointestinal system.
配列類似性Belongs to the peptidase M2 family.
翻訳後修飾N-glycosylation on Asn-90 may limit SARS infectivity.