製品の概要

製品の詳細

  • 由来
    Synthetic
  • アミノ酸配列
    • 生物種
      Human
    • 配列
      AARPLPVSPARAL-C
    • 領域
      2 to 15

関連製品

特性

Our Abpromise guarantee covers the use of ab45636 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Blocking - Blocking peptide for Anti-ADAM12 antibody (ab28747)

  • 製品の状態
    Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

関連情報

  • 別名
    • A disintegrin and metalloproteinase domain 12
    • ADA12_HUMAN
    • ADAM 12
    • ADAM metallopeptidase domain 12
    • ADAM12
    • CAR10
    • Disintegrin and metalloproteinase domain-containing protein 12
    • MCMP
    • MCMPMltna
    • Meltrin alpha
    • Meltrin-alpha
    • Metalloprotease disintegrin 12 transmembrane
    • MLTN
    • MLTNA
    • OTTHUMP00000046766
    see all
  • 機能
    Involved in skeletal muscle regeneration, specifically at the onset of cell fusion. Also involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors.
  • 組織特異性
    Isoform 1 is expressed in placenta and skeletal, cardiac, and smooth muscle. Isoform 2 seems to be expressed only in placenta or in embryo and fetus. Both forms were expressed in some tumor cells lines. Not detected in brain, lung, liver, kidney or pancreas.
  • 配列類似性
    Contains 1 disintegrin domain.
    Contains 1 EGF-like domain.
    Contains 1 peptidase M12B domain.
  • ドメイン
    The cysteine-rich domain supports cell adhesion through syndecans and triggers signaling events that lead to beta-1 integrin-dependent cell spreading. In carcinomas cells the binding of this domain to syndecans does not allow the integrin-mediated cell spreading.
    The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • 翻訳後修飾
    The precursor is cleaved by a furin endopeptidase.
  • 細胞内局在
    Secreted and Cell membrane.
  • Information by UniProt

参考文献

ab45636 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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