製品の概要

製品の詳細

  • 由来Synthetic
  • アミノ酸配列
    • 生物種Human

関連製品

特性

Our Abpromise guarantee covers the use of ab41847 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Blocking - Blocking peptide for Anti-AATF antibody (ab39631)

  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: 0.02% Sodium Azide
    Constituents: 0.1% BSA, PBS, pH 7.2

関連情報

  • 別名
    • AATF
    • AATF_HUMAN
    • Apoptosis antagonizing transcription factor
    • Apoptosis-antagonizing transcription factor
    • CHE 1
    • CHE1
    • DED
    • Protein AATF
    • Rb binding protein Che 1
    • Rb-binding protein Che-1
    see all
  • 機能May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date.
  • 組織特異性Ubiquitously expressed. Expressed at high levels in brain, heart, kidney, placenta and thymus.
  • 配列類似性Belongs to the AATF family.
  • 翻訳後修飾Hyperphosphorylated during the G1/S phase transition.
  • 細胞内局在Nucleus > nucleolus.
  • Information by UniProt

Human AATF peptide (ab41847) 使用論文

ab41847 has not yet been referenced specifically in any publications.

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