Reacts with herpes simplex virus type 2.
Does not crossreact with tissue culture isolates of respiratory syncytial virus, influenza virus types A and B, parainfluenza virus types 1, 2, 3 and 4b, adenovirus, herpes simplex virus type 1, varicella-zoster virus, cytomegalovirus, mumps virus, measles virus, ECHOvirus 19, coxsackie B4 virus, poliovirus types 1, 2 and 3 or negative tissue culture cells used in routine virus isolation
Herpes simplex virus type 2 (Parker strain).
Immunofluorescence - Acetone-fixed HEp 2 cells infected with Herpes simplex virus type 2.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/25 - 1/50.
Herpes simplex type 2 (HSV2) belongs to a family that includes HSV1, Epstein-Barr virus (EBV) and Varicella zoster (chicken pox) virus. HSV1 and HSV2 are extremely difficult to distinguish from each other. These viruses have a DNA genome, an icosahedral protein coat and are encased in a lipid membrane derived from the nuclear membrane of the last host. These viruses are capable of entering a latent phase where the host shows no visible sign of infection and levels of infectious agent become very low. During the latent phase the viral DNA is integrated into the genome of the host cell.