製品の概要

  • 製品名Anti-HSP90B2P antibody
  • 製品の詳細
    Rabbit polyclonal to HSP90B2P
  • アプリケーション適用あり: WB, ELISA, IHC-Pmore details
  • 種交差性
    交差種: Mouse, Rat, Chicken, Human, Drosophila melanogaster, Monkey
    交差が予測される動物種: Rabbit, Cow, Dog, Pig, Xenopus laevis, Zebrafish, Cynomolgus Monkey, Syrian Hamster, Orangutan
  • 免疫原

    Synthetic peptide corresponding to Human HSP90B2P aa 289-300 (C terminal).
    Sequence:

    SQYGWSGNMERI

  • ポジティブ・コントロール
    • Human kidney tissue.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • バッファーPreservative: 0.01% Sodium Azide
    Constituents: 0.15M Sodium chloride, 0.02M Potassium phosphate, pH 7.2
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab64182 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/2500. Predicted molecular weight: 46 kDa.
ELISA 1/5000 - 1/25000.
IHC-P Use a concentration of 2.5 µg/ml.

ターゲット情報

  • 関連性Hsp90 is a member of the heat shock protein 90 family that functions as a molecular chaperone and has ATPase activity. Hsp90 family proteins are highly conserved between isoforms and species. Several signal transduction pathways depend on Hsp90 function including erbB2, steroid hormone receptors (such as androgen, progesterone, glucocorticoid, and aryl-hydrocarbon), and hypoxia sensing (Hif1alpha). Recent reports show that tumor cells are more sensitive to Hsp90 inhibition and that Hsp90 from tumor cells is more sensitive to small molecule inhibitors (eg 17AAG). The mechanism of this differential sensitivity of normal versus tumor Hsp90 is not known (although mutation has been ruled out). One possible mechanism may be differences in post-translational modification of tumor Hsp90. Hsp90 is a cytoplasmic protein that forms a homodimer in vivo, and interacts with TOM34, AHSA1, HDAC6 and SMYD3.
  • 細胞内局在Endoplasmic reticulum
  • 参照データベース
  • 別名
    • GRP94P1 antibody
    • Heat shock protein 90kDa beta (Grp94) member 2 antibody
    • HSP antibody
    • HSPCP2 antibody
    • Putative endoplasmin like protein antibody
    • Putative heat shock protein 90 kDa beta member 2 antibody
    • TRA1P1 antibody
    • TRAP1 antibody
    see all

Anti-HSP90B2P antibody 画像

  • ab64182 (2.5ug/ml) staining HSP90B2P in human kidney tissue by immunohistochemistry using formalin-fixed, paraffin-embedded tissue.

Anti-HSP90B2P antibody (ab64182) 使用論文

ab64182 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab64182.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"