保存方法 Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
バッファー Preservative: 0.02% Sodium Azide
Constituents: 50% Glycerol, 1.0% BSA, PBS
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精製度 Protein A purified
Abpromise guarantee covers the use of
in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 1 - 4 µg/ml. Detects a band of approximately 105 kDa (predicted molecular weight: 97 kDa).
Use a concentration of 10 - 20 µg/ml.
機能 Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities.
組織特異性 Highly expressed in testis. Present at lower levels in most brain regions, except cerebellum. Overexpressed in cancer cells.
配列類似性 Belongs to the heat shock protein 70 family.
翻訳後修飾 Phosphorylation on Ser-509 may be important for regulation of the HSPA8/HSC70 chaperone activity.
Information by UniProt
Antigen NY CO 25 antibody
Antigen NY-CO-25 antibody
Anti-Hsp105 antibody (ab24503) 使用論文
This product has been referenced in:
The Mammalian disaggregase machinery: hsp110 synergizes with hsp70 and hsp40 to catalyze protein disaggregation and reactivation in a cell-free system. PLoS One 6:e26319 (2011).
Read more (PubMed: 22022600) »
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"