製品の概要

  • 製品名Anti-HSD11B2 antibody
    HSD11B2 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to HSD11B2
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Cow, Pig, Chimpanzee, Macaque Monkey, Gorilla, Orangutan
  • 免疫原

    Synthetic peptide conjugated to KLH derived from within residues 250 - 350 of Human HSD11B2.

  • ポジティブ・コントロール
    • This antibody gave a positive signal in both Human Placenta and Kidney tissue lysates.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab117886 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Detects a band of approximately 40 kDa (predicted molecular weight: 44 kDa).

ターゲット情報

  • 機能Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids.
  • 組織特異性Found in placenta, kidney, pancreas, prostate, ovary, small intestine and colon.
  • 関連疾患Defects in HSD11B2 are the cause of apparent mineralocorticoid excess (AME) [MIM:218030]. AME is a potentially fatal disease characterized by severe juvenile low-renin hypertension, sodium retention, hypokalemia and low levels of aldosterone. It often leads to nephrocalcinosis.
  • 配列類似性Belongs to the short-chain dehydrogenases/reductases (SDR) family.
  • 細胞内局在Microsome. Endoplasmic reticulum.
  • Information by UniProt
  • 参照データベース
  • 別名
    • 11 beta HSD2 antibody
    • 11 beta hydroxysteroid dehydrogenase type 2 antibody
    • 11 DH2 antibody
    • 11-beta-HSD2 antibody
    • 11-beta-hydroxysteroid dehydrogenase type 2 antibody
    • 11-DH2 antibody
    • AME antibody
    • AME1 antibody
    • Corticosteroid 11 beta dehydrogenase isozyme 2 antibody
    • Corticosteroid 11-beta-dehydrogenase isozyme 2 antibody
    • DHI2_HUMAN antibody
    • HSD11B2 antibody
    • HSD11K antibody
    • HSD2 antibody
    • Hydroxysteroid 11 beta dehydrogenase 2 antibody
    • Hydroxysteroid 11 beta dehydrogenase isoenzyme 2 antibody
    • NAD dependent 11 beta hydroxysteroid dehydrogenase antibody
    • NAD-dependent 11-beta-hydroxysteroid dehydrogenase antibody
    • SDR9C3 antibody
    • Short chain dehydrogenase/reductase family 9C, member 3 antibody
    see all

Anti-HSD11B2 antibody 画像

  • All lanes : Anti-HSD11B2 antibody (ab117886) at 1 µg/ml

    Lane 1 : Human placenta tissue lysate - total protein (ab29745)
    Lane 2 : Human kidney tissue lysate - total protein (ab30203)

    Lysates/proteins at 10 µg per lane.

    Secondary
    Goat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilution
    Developed using the ECL technique

    Performed under reducing conditions.

    Predicted band size : 44 kDa
    Observed band size : 40 kDa (why is the actual band size different from the predicted?)
    Additional bands at : 13 kDa,150 kDa. We are unsure as to the identity of these extra bands.

    Exposure time : 8 minutes

Anti-HSD11B2 antibody (ab117886) 使用論文

ab117886 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"