製品の概要

製品の詳細

  • 由来
    Synthetic
  • アミノ酸配列
    • 生物種
      Human
    • 配列
      C-TSYNMDRFINK
    • 領域
      281 to 291

関連製品

特性

Our Abpromise guarantee covers the use of ab45666 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Blocking - Blocking peptide for Anti-HSD11B1 antibody (ab27501)

  • 製品の状態
    Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

関連情報

  • 別名
    • 11 beta HSD 1
    • 11 beta HSD1
    • 11 beta hydroxysteroid dehydrogenase 1
    • 11 DH
    • 11-beta hydroxysteroid dehydrogenase, type 1
    • 11-beta-HSD1
    • 11-beta-hydroxysteroid dehydrogenase 1
    • 11-DH
    • 11DH
    • Corticosteroid 11 beta dehydrogenase isozyme 1
    • Corticosteroid 11-beta-dehydrogenase isozyme 1
    • CORTRD2
    • DHI1_HUMAN
    • HDL
    • HSD 11
    • HSD11
    • HSD11B
    • HSD11B1
    • HSD11L
    • Hydroxysteroid (11 beta) dehydrogenase
    • Hydroxysteroid (11 beta) dehydrogenase 1
    • MGC13539
    • SDR26C1
    • short chain dehydrogenase/reductase family 26C, member 1
    see all
  • 機能
    Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta-hydroxycholesterol.
  • 組織特異性
    Widely expressed. Highest expression in liver.
  • 関連疾患
    Defects in HSD11B1 are a cause of cortisone reductase deficiency (CRD) [MIM:604931]. In CRD, activation of cortisone to cortisol does not occur, resulting in adrenocorticotropin-mediated androgen excess and a phenotype resembling polycystic ovary syndrome (PCOS).
  • 配列類似性
    Belongs to the short-chain dehydrogenases/reductases (SDR) family.
  • 翻訳後修飾
    Glycosylated.
  • 細胞内局在
    Endoplasmic reticulum membrane.
  • Information by UniProt

参考文献

ab45666 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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