製品の概要

  • 製品名Anti-HSD11B1 antibody
    HSD11B1 一次抗体 製品一覧
  • 製品の詳細
    Goat polyclonal to HSD11B1
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Mouse
    交差が予測される動物種: Rat
  • 免疫原

    Synthetic peptide:

    C-TARSEEGLQKVVSR

    (with a Cysteine residue linker), corresponding to internal sequence amino acids 64-77 of Mouse HSD11B1 according to NP_032314.2.

  • ポジティブ・コントロール
    • Mouse Lung lysate

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab123496 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 0.3 - 1 µg/ml. Predicted molecular weight: 32.4 kDa. Calculated MW of 32.4kDa according to NP_032314.2

ターゲット情報

  • 機能Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta-hydroxycholesterol.
  • 組織特異性Widely expressed. Highest expression in liver.
  • 関連疾患Defects in HSD11B1 are a cause of cortisone reductase deficiency (CRD) [MIM:604931]. In CRD, activation of cortisone to cortisol does not occur, resulting in adrenocorticotropin-mediated androgen excess and a phenotype resembling polycystic ovary syndrome (PCOS).
  • 配列類似性Belongs to the short-chain dehydrogenases/reductases (SDR) family.
  • 翻訳後修飾Glycosylated.
  • 細胞内局在Endoplasmic reticulum membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • 11 beta HSD 1 antibody
    • 11 beta HSD1 antibody
    • 11 beta hydroxysteroid dehydrogenase 1 antibody
    • 11 DH antibody
    • 11-beta hydroxysteroid dehydrogenase, type 1 antibody
    • 11-beta-HSD1 antibody
    • 11-beta-hydroxysteroid dehydrogenase 1 antibody
    • 11-DH antibody
    • 11DH antibody
    • Corticosteroid 11 beta dehydrogenase isozyme 1 antibody
    • Corticosteroid 11-beta-dehydrogenase isozyme 1 antibody
    • CORTRD2 antibody
    • DHI1_HUMAN antibody
    • HDL antibody
    • HSD 11 antibody
    • HSD11 antibody
    • HSD11B antibody
    • HSD11B1 antibody
    • HSD11L antibody
    • Hydroxysteroid (11 beta) dehydrogenase antibody
    • Hydroxysteroid (11 beta) dehydrogenase 1 antibody
    • MGC13539 antibody
    • SDR26C1 antibody
    • short chain dehydrogenase/reductase family 26C, member 1 antibody
    see all

Anti-HSD11B1 antibody 画像

  • Anti-HSD11B1 antibody (ab123496) at 0.3 µg/ml + Mouse Lung lysate in RIPA buffer at 35 µg
    Developed using the ECL technique

    Predicted band size : 32.4 kDa

Anti-HSD11B1 antibody (ab123496) 使用論文

ab123496 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"