Anti-HSD11B1 抗体 (ab109554)

製品の概要

  • 製品名Anti-HSD11B1 antibody
    HSD11B1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to HSD11B1
  • アプリケーション適用あり: WB, IHC-P, IHC-Fr, ICCmore details
  • 種交差性
    交差種: Mouse, Rat, Human
    交差が予測される動物種: Rabbit, Dog, Pig, Cynomolgus Monkey
  • 免疫原

    Synthetic peptide:

    DDIHHVRKSM EVNFL

    , corresponding to internal sequence amino acids 131-145 of Human HSD11B1.

  • ポジティブ・コントロール
    • HeLa cell lysate, SMMC cell lysate, Raji cell lysate, Colo320 cell lysate.

法規制情報

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab109554 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 32 kDa.
IHC-P Use a concentration of 1 µg/ml.
IHC-Fr Use a concentration of 1 µg/ml.
ICC Use a concentration of 1 µg/ml.

ターゲット情報

  • 機能Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta-hydroxycholesterol.
  • 組織特異性Widely expressed. Highest expression in liver.
  • 関連疾患Defects in HSD11B1 are a cause of cortisone reductase deficiency (CRD) [MIM:604931]. In CRD, activation of cortisone to cortisol does not occur, resulting in adrenocorticotropin-mediated androgen excess and a phenotype resembling polycystic ovary syndrome (PCOS).
  • 配列類似性Belongs to the short-chain dehydrogenases/reductases (SDR) family.
  • 翻訳後修飾Glycosylated.
  • 細胞内局在Endoplasmic reticulum membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • 11 beta HSD 1 antibody
    • 11 beta HSD1 antibody
    • 11 beta hydroxysteroid dehydrogenase 1 antibody
    • 11 DH antibody
    • 11-beta hydroxysteroid dehydrogenase, type 1 antibody
    • 11-beta-HSD1 antibody
    • 11-beta-hydroxysteroid dehydrogenase 1 antibody
    • 11-DH antibody
    • 11DH antibody
    • Corticosteroid 11 beta dehydrogenase isozyme 1 antibody
    • Corticosteroid 11-beta-dehydrogenase isozyme 1 antibody
    • CORTRD2 antibody
    • DHI1_HUMAN antibody
    • HDL antibody
    • HSD 11 antibody
    • HSD11 antibody
    • HSD11B antibody
    • HSD11B1 antibody
    • HSD11L antibody
    • Hydroxysteroid (11 beta) dehydrogenase antibody
    • Hydroxysteroid (11 beta) dehydrogenase 1 antibody
    • MGC13539 antibody
    • SDR26C1 antibody
    • short chain dehydrogenase/reductase family 26C, member 1 antibody
    see all

Anti-HSD11B1 antibody 画像

  • All lanes : Anti-HSD11B1 antibody (ab109554) at 1 µg/ml

    Lane 1 : HeLa whole cell lysate
    Lane 2 : SMMC whole cell lysate
    Lane 3 : Raji whole cell lysate
    Lane 4 : Colo320 whole cell lysate


    Predicted band size : 32 kDa

Anti-HSD11B1 antibody (ab109554) 使用論文

ab109554 has not yet been referenced specifically in any publications.

Product Wall

Abcam guarantees this product to work in the species/application used in this Abreview.
Application Western blot
Sample Human Cell lysate - whole cell (HK2 cell (human kidney proximal tubule))
Loading amount 30 µg
Specification HK2 cell (human kidney proximal tubule)
Gel Running Conditions Reduced Denaturing (12)
Blocking step Milk as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 7% · Temperature: 20°C
Username

Mr. Dongil Kim

Verified customer

投稿 May 03 2013

Thank you for confirming these details and for your cooperation. The details provided enable us to closely monitor the quality of our products. I am sorry for any inconvenience that this product has caused. As requested, I have issued a free of char...

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Thank you for confirming these details and for your cooperation. The details provided enable us to closely monitor the quality of our products.

I am sorry this product did not perform as stated on the datasheet and for the inconvenience this...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"