Anti-Hsc70 抗体 (ab52057)

製品の概要

• 製品名Anti-Hsc70 antibody
  Hsc70 一次抗体 製品一覧
• 製品の詳細
  Goat polyclonal to Hsc70
• 特異性This antibody is expected to recognise isoform 1 (NP_006588.1) only.
• アプリケーション適用あり: WB, ELISAmore details
• 種交差性
  交差種: Human
  交差が予測される動物種: Mouse, Rat, Horse, Hamster, Cow, Dog, Orangutan
• 免疫原

  Synthetic peptide:

  C-EKLQGKINDEDKQK

  , corresponding to internal sequence amino acids 556-569 of Human Hsc70
  Run BLAST with Run BLAST with
• ポジティブ･コントロール
  • A431 cell lysate

製品の特性

• 製品の状態Liquid
• 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• バッファーPreservative: 0.02% Sodium Azide
  Constituents: 0.5% BSA, Tris buffered saline, pH 7.3
• Concentration information loading...
• 精製度Immunogen affinity purified
• 特記事項（精製）Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
• ポリ/モノポリクローナル
• アイソタイプIgG
• 研究分野
  • Signal Transduction
  • Protein Trafficking
  • Chaperones
  • Heat Shock Proteins

関連製品

• Compatible Secondaries
  • Donkey Anti-Goat IgG H&L (Alexa Fluor® 488) (ab150129)
  • Donkey Anti-Goat IgG H&L (HRP) (ab205723)

アプリケーション

ターゲット情報

• 機能Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Isoform 2 may function as an endogenous inhibitory regulator of HSC70 by competing the co-chaperones.
• 組織特異性Ubiquitous.
• 配列類似性Belongs to the heat shock protein 70 family.
• ドメインThe N-terminal 1-386 residues constitute the ATPase domain, while residues 387-646 form the peptide-binding domain.
• 翻訳後修飾Phosphorylated upon DNA damage, probably by ATM or ATR.
  ISGylated.
• 細胞内局在Cytoplasm. Melanosome. Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Translocates rapidly from the cytoplasm to the nuclei, and especially to the nucleoli, upon heat shock. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

• Target information above from: UniProt accession P11142 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 参照データベース
  • Entrez Gene: 281831 Cow
  • Entrez Gene: 3312 Human
  • Entrez Gene: 15481 Mouse
  • Entrez Gene: 24468 Rat
  • Omim: 600816 Human
  • SwissProt: P11142 Human
  • SwissProt: P63017 Mouse
  • SwissProt: P63018 Rat

  • Unigene: 180414 Human
  • Unigene: 290774 Mouse
  • Unigene: 336743 Mouse
  • Unigene: 351377 Mouse
  • Unigene: 412745 Mouse
  • Unigene: 120392 Rat
  • Unigene: 201298 Rat

  see all
• 別名
  • 2410008N15Rik antibody
  • Constitutive heat shock protein 70 antibody
  • Epididymis luminal protein 33 antibody

  • Epididymis secretory sperm binding protein Li 72p antibody
  • Heat shock 70 kDa protein 8 antibody
  • Heat shock 70kD protein 10 antibody
  • Heat shock 70kD protein 8 antibody
  • Heat shock 70kDa protein 8 antibody
  • Heat shock cognate 71 kDa protein antibody
  • Heat shock cognate protein 54 antibody
  • Heat shock cognate protein 71 kDa antibody
  • Heat shock protein 8 antibody
  • Heat shock protein A8 antibody
  • Heat-shock70-KD protein 10, formerly antibody
  • HEL 33 antibody
  • HEL S 72p antibody
  • HSC54 antibody
  • HSC71 antibody
  • Hsc73 antibody
  • HSP71 antibody
  • HSP73 antibody
  • HSP7C_HUMAN antibody
  • HSPA10 antibody
  • HSPA8 antibody
  • LAP1 antibody
  • Lipopolysaccharide associated protein 1 antibody
  • LPS associated protein 1 antibody
  • LPS associated protein antibody
  • MGC102007 antibody
  • MGC106514 antibody
  • MGC114311 antibody
  • MGC118485 antibody
  • MGC131511 antibody
  • MGC29929 antibody
  • N-myristoyltransferase inhibitor protein 71 antibody
  • NIP71 antibody

  see all