製品の概要

  • 製品名Anti-Hrk antibody
    Hrk 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Hrk
  • アプリケーション適用あり: ELISA, IHC-Pmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide:

    AQLTAARLKALGDELHQRTMW

    conjugated to KLH, corresponding to amino acids 30-50 of Human Hrk

  • ポジティブ・コントロール
    • Human breast carcinoma tissue.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • バッファーPreservative: 0.09% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • 精製度Protein G purified
  • 特記事項(精製)ab59907 waa purified through a protein G column and eluted out with both high and low pH buffers. It was neutralized immediately after elution then followed by dialysis against PBS.
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab59907 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ELISA 1/1000.
IHC-P 1/50 - 1/100.

ターゲット情報

  • 関連性Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Hrk, a pro-apoptotic member of the Bcl-2 homology domain-3 (BH3) group of the Bcl-2 family of proteins, was identified as a novel protein induced during programmed neuronal death. It lacks significant homology to other Bcl-2 family members except for an 8-amino acid region that is similar to the BH3 motif of Bik. Hrk regulates apoptosis through interaction with the anti-apoptotic proteins Bcl-2 and Bcl-XL via this domain. It does not interact with the pro-apoptotic proteins Bax, Bak, or Bcl-XS. Hrk localizes to mitochondrial membranes in a pattern similar to that previously reported for Bcl-2 and Bcl-XL. Despite its predicted molecular weight, Hrk often migrates at 12-15 kDa.
  • 参照データベース
  • 別名
    • Activator of apoptosis harakiri antibody
    • Activator of apoptosis Hrk antibody
    • BCL2 interacting protein antibody
    • BH3 interacting domain protein 3 antibody
    • BID3 antibody
    • DP5 antibody
    • Harakiri BCL2 interacting protein antibody
    • Human brain 3UTR of mRNA for neuronal death protein partial sequence antibody
    • Neuronal death protein DP5 antibody
    see all

Anti-Hrk antibody 画像

  • ab59907, at a 1/50 dilution, staining Hrk in formalin-fixed, paraffin-embedded human breast carcinoma tissue by Immunohistochemistry. The primary antibody was peroxidase-conjugated to the secondary antibody, followed by AEC staining.

Anti-Hrk antibody (ab59907) 使用論文

This product has been referenced in:
  • Barrera-Vilarmau S  et al. Intrinsic order and disorder in the bcl-2 member harakiri: insights into its proapoptotic activity. PLoS One 6:e21413 (2011). ELISA ; Human . Read more (PubMed: 21731739) »
  • Sborgi L  et al. Characterization of a Novel Interaction between Bcl-2 Members Diva and Harakiri. PLoS One 5:e15575 (2010). ELISA ; Human . Read more (PubMed: 21209886) »

See all 2 Publications for this product

Product Wall

There are currently no Abreviews or Questions for ab59907.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"