製品の概要

  • 製品名Anti-HNF1 beta antibody
    HNF1 beta 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to HNF1 beta
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, between amino acids 505-536 from the C-terminal region of Human TCF2 (NP_000449.1, NP_001159395.1).

  • ポジティブ・コントロール
    • MDA-MB231 cell line lysate

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
  • バッファーPreservative: 0.09% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • 特記事項(精製)ab107118 is purified through a protein A column, followed by peptide affinity purification.
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab107118 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/100 - 1/500. Predicted molecular weight: 61 kDa.

ターゲット情報

  • 機能Transcription factor, probably binds to the inverted palindrome 5'-GTTAATNATTAAC-3'.
  • 関連疾患Defects in HNF1B are the cause of renal cysts and diabetes syndrome (RCAD) [MIM:137920]; also called maturity-onset diabetes of the young type 5 (MODY5) or familial hypoplastic glomerulocystic kidney disease (GCKD). RCAD is an autosomal dominant disorder comprising non-diabetic renal disease resulting from abnormal renal development, and diabetes, which in some cases occurs earlier than age 25 years and is thus consistent with a diagnosis of maturity-onset diabetes of the young (MODY5). The renal disease is highly variable and includes renal cysts, glomerular tufts, aberrant nephrogenesis, primitive tubules, irregular collecting systems, oligomeganephronia, enlarged renal pelves, abnormal calyces, small kidney, single kidney, horseshoe kidney, and hyperuricemic nephropathy.
    Defects in HNF1B may be rare genetic risk factor contributing to the development of non-insulin-dependent diabetes mellitus (NIDDM) [MIM:125853]. NIDDM is characterized by an autosomal dominant mode of inheritance, onset during adulthood and insulin resistance.
    Defects in HNF1B may be a cause of susceptibility to prostate cancer hereditary type 11 (HPC11) [MIM:611955]. It is a condition associated with familial predisposition to cancer of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma.
  • 配列類似性Belongs to the HNF1 homeobox family.
    Contains 1 homeobox DNA-binding domain.
  • 細胞内局在Nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • FJHN antibody
    • Hepatocyte nuclear factor 1 beta antibody
    • Hepatocyte nuclear factor 1-beta antibody
    • HNF 1B antibody
    • HNF 2 antibody
    • HNF-1-beta antibody
    • HNF-1B antibody
    • HNF1 beta antibody
    • HNF1 homeobox B antibody
    • HNF1B antibody
    • HNF1B_HUMAN antibody
    • HNF1beta antibody
    • HNF2 antibody
    • Homeoprotein LF B3 antibody
    • Homeoprotein LFB3 antibody
    • HPC11 antibody
    • LF B3 antibody
    • LFB3 antibody
    • MODY 5 antibody
    • MODY5 antibody
    • TCF 2 antibody
    • TCF 2 protein antibody
    • TCF-2 antibody
    • TCF2 antibody
    • TCF2 protein antibody
    • Transcription factor 2 antibody
    • Transcription factor 2 hepatic antibody
    • Variant hepatic nuclear factor 1 antibody
    • Variant hepatic nuclear factor antibody
    • VHNF 1 antibody
    • vHNF1 antibody
    see all

Anti-HNF1 beta antibody 画像

  • Anti-HNF1 beta antibody (ab107118) at 1/100 dilution + MDA-MB231 cell line lysate at 35 µg

    Predicted band size : 61 kDa

Anti-HNF1 beta antibody (ab107118) 使用論文

ab107118 has not yet been referenced specifically in any publications.

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