製品の概要

  • 製品名Anti-HNF1 alpha antibody
    HNF1 alpha 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to HNF1 alpha
  • アプリケーション適用あり: WB, IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Cow, Pig
  • 免疫原

    Recombinant fragment corresponding to Human HNF1 aa 35-238.
    Database link: P20823

  • ポジティブ・コントロール
    • WB: HepG2 whole cell lysate IHC-P: A549 Xenograft

法規制情報

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab96777 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/3000. Predicted molecular weight: 67 kDa.
IHC-P 1/100 - 1/250.

ターゲット情報

  • 機能Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver. Required for the expression of several liver specific genes. Binds to the inverted palindrome 5'-GTTAATNATTAAC-3'.
  • 組織特異性Liver.
  • 関連疾患Defects in HNF1A are a cause of hepatic adenomas familial (HEPAF) [MIM:142330]. Hepatic adenomas are rare benign liver tumors of presumable epithelial origin that develop in an otherwise normal liver. Hepatic adenomas may be single or multiple. They consist of sheets of well-differentiated hepatocytes that contain fat and glycogen and can produce bile. Bile ducts or portal areas are absent. Kupffer cells, if present, are reduced in number and are non-functional. Conditions associated with adenomas are insulin-dependent diabetes mellitus and glycogen storage diseases (types 1 and 3). Note=Bi-allelic inactivation of HNF1A, whether sporadic or associated with MODY3, may be an early step in the developmant of some hepatocellular carcinomas.
    Defects in HNF1A are the cause of maturity-onset diabetes of the young type 3 (MODY3) [MIM:600496]; also symbolized MODY-3. MODY is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.
    Defects in HNF1A are the cause of susceptibility to diabetes mellitus insulin-dependent type 20 (IDDM20) [MIM:612520]. IDDM20 is a multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These features can result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
  • 配列類似性Belongs to the HNF1 homeobox family.
    Contains 1 homeobox DNA-binding domain.
  • 細胞内局在Nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Albumin proximal factor antibody
    • Hepatic nuclear factor 1 alpha antibody
    • Hepatic nuclear factor 1 antibody
    • Hepatic transcription factor 1 alpha antibody
    • Hepatic transcription factor 1 antibody
    • Hepatocyte nuclear factor 1-alpha antibody
    • HNF 1 antibody
    • HNF 1A antibody
    • HNF-1-alpha antibody
    • HNF-1A antibody
    • hnf1a antibody
    • HNF1A_HUMAN antibody
    • Interferon production regulator factor antibody
    • LF B1 antibody
    • LF B1 hepatic nuclear factor antibody
    • LFB 1 antibody
    • LFB1 antibody
    • LFB1 hepatic nuclear factor antibody
    • Liver specific transcription factor LF B1 antibody
    • Liver specific transcription factor LFB1 antibody
    • Liver-specific transcription factor LF-B1 antibody
    • Maturity onset diabetes of the young 3 antibody
    • MODY 3 antibody
    • MODY3 antibody
    • TCF 1 antibody
    • TCF-1 antibody
    • TCF1 antibody
    • Transcription factor 1 antibody
    • Transcription factor 1 hepatic antibody
    see all

Anti-HNF1 alpha antibody 画像

  • Anti-HNF1 alpha antibody (ab96777) at 1/1000 dilution + HepG2 whole cell lysate at 30 µg

    Predicted band size : 67 kDa
    7.5% SDS PAGE
  • ab96777, at a 1/100 dilution, staining HNF1 in paraffin embedded A549 Xenograft by Immunohistochemistry.

Anti-HNF1 alpha antibody (ab96777) 使用論文

ab96777 has not yet been referenced specifically in any publications.

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Vielen Dank für Ihre Anfrage.

In der Tat bezieht sich das angegebene Molekulargewicht von 67 kDa auf den SwissProt-Eintrag von HNF1 (P20823), der nur den vorhandenen Proteinanteil und keine Modifikationen berücksichtigt. Das unprozessierte H...

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La secuencia del inmunógeno para este anticuerpo (ab96777) muestra un porcentaje de homología del 62% con la unidad HNF1 beta, por lo que es improbable que haya reactividad cruzada con esta isoforma. Espero que esta información os sea de utilidad. No...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"