製品の概要

  • 製品名Anti-HNF1 alpha antibody
    HNF1 alpha 一次抗体 製品一覧
  • 製品の詳細
    Goat polyclonal to HNF1 alpha
  • アプリケーション適用あり: IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Chicken, Hamster
  • 免疫原

    Synthetic peptide:

    C-VIETFISTQMASSSQ

    , corresponding to amino acids 617-631 of Human HNF1 (NP_000536.5).

  • ポジティブ・コントロール
    • Human Kidney tissue

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab118580 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P Use a concentration of 3.75 - 7.5 µg/ml.

ターゲット情報

  • 機能Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver. Required for the expression of several liver specific genes. Binds to the inverted palindrome 5'-GTTAATNATTAAC-3'.
  • 組織特異性Liver.
  • 関連疾患Defects in HNF1A are a cause of hepatic adenomas familial (HEPAF) [MIM:142330]. Hepatic adenomas are rare benign liver tumors of presumable epithelial origin that develop in an otherwise normal liver. Hepatic adenomas may be single or multiple. They consist of sheets of well-differentiated hepatocytes that contain fat and glycogen and can produce bile. Bile ducts or portal areas are absent. Kupffer cells, if present, are reduced in number and are non-functional. Conditions associated with adenomas are insulin-dependent diabetes mellitus and glycogen storage diseases (types 1 and 3). Note=Bi-allelic inactivation of HNF1A, whether sporadic or associated with MODY3, may be an early step in the developmant of some hepatocellular carcinomas.
    Defects in HNF1A are the cause of maturity-onset diabetes of the young type 3 (MODY3) [MIM:600496]; also symbolized MODY-3. MODY is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.
    Defects in HNF1A are the cause of susceptibility to diabetes mellitus insulin-dependent type 20 (IDDM20) [MIM:612520]. IDDM20 is a multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These features can result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
  • 配列類似性Belongs to the HNF1 homeobox family.
    Contains 1 homeobox DNA-binding domain.
  • 細胞内局在Nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Albumin proximal factor antibody
    • Hepatic nuclear factor 1 alpha antibody
    • Hepatic nuclear factor 1 antibody
    • Hepatic transcription factor 1 alpha antibody
    • Hepatic transcription factor 1 antibody
    • Hepatocyte nuclear factor 1-alpha antibody
    • HNF 1 antibody
    • HNF 1A antibody
    • HNF-1-alpha antibody
    • HNF-1A antibody
    • hnf1a antibody
    • HNF1A_HUMAN antibody
    • Interferon production regulator factor antibody
    • LF B1 antibody
    • LF B1 hepatic nuclear factor antibody
    • LFB 1 antibody
    • LFB1 antibody
    • LFB1 hepatic nuclear factor antibody
    • Liver specific transcription factor LF B1 antibody
    • Liver specific transcription factor LFB1 antibody
    • Liver-specific transcription factor LF-B1 antibody
    • Maturity onset diabetes of the young 3 antibody
    • MODY 3 antibody
    • MODY3 antibody
    • TCF 1 antibody
    • TCF-1 antibody
    • TCF1 antibody
    • Transcription factor 1 antibody
    • Transcription factor 1 hepatic antibody
    see all

Anti-HNF1 alpha antibody 画像

  • Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE) using ab118580 at a concentration of 7.5 µg/ml.

Anti-HNF1 alpha antibody (ab118580) 使用論文

ab118580 has not yet been referenced specifically in any publications.

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