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機能
Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function.
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組織特異性
Expressed in kidney, lung, pancreas, testis, skeletal muscle, heart, thyroid gland, pituitary gland, prostate and uterus. Low expression in liver, spleen, placenta and ovaries.
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配列類似性
Belongs to the HMGN family.
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細胞内局在
Nucleus.
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Information by UniProt
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参照データベース
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別名
- DKFZp686E20226 antibody
- FLJ42187 antibody
- High mobility group nucleosomal binding domain 3 antibody
- High mobility group nucleosome-binding domain-containing protein 3 antibody
- HMGN3 antibody
- HMGN3_HUMAN antibody
- OTTHUMP00000016772 antibody
- OTTHUMP00000016773 antibody
- PNAS 24 antibody
- PNAS 25 antibody
- PNAS24 antibody
- PNAS25 antibody
- Thyroid hormone receptor interacting protein 7 antibody
- Thyroid receptor-interacting protein 7 antibody
- TR-interacting protein 7 antibody
- TRIP 7 antibody
- TRIP-7 antibody
- TRIP7 antibody
see all