製品の概要

  • 製品名Anti-HMGCS2 antibody
    HMGCS2 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to HMGCS2
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Rabbit, Horse, Guinea pig, Cat, Dog
  • 免疫原

    Synthetic peptide corresponding to a region within C terminal amino acids 444-493 (DLPKRLASRK CVSPEEFTEI MNQREQFYHK VNFSPPGDTN SLFPGTWYLE) of Human HMGCS2 (NP_005509)

  • ポジティブ・コントロール
    • Human fetal liver cell lysate

アプリケーション

Our Abpromise guarantee covers the use of ab104807 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1.25 µg/ml. Predicted molecular weight: 57 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

ターゲット情報

  • 機能This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.
  • 組織特異性High expression in liver and colon. Low expression in testis, heart, skeletal muscle and kidney.
  • パスウェイMetabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 2/3.
  • 関連疾患Defects in HMGCS2 are the cause of HMG-CoA synthase deficiency (HMGCS deficiency) [MIM:605911]; also known as deficiency of mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase 2. Affected individuals present with severe hypoketotic hypoglycemia, mild hepatomegaly, or fatty liver, and a nondiagnostic pattern of urinary organic acids with increase of medium and short chain dicarboxylic acids.
  • 配列類似性Belongs to the HMG-CoA synthase family.
  • 細胞内局在Mitochondrion.
  • Information by UniProt
  • 参照データベース
  • 別名
    • 3 hydroxy 3 methylglutaryl Coenzyme A synthase 2 (mitochondrial) antibody
    • 3 hydroxy 3 methylglutaryl Coenzyme A synthase 2 antibody
    • 3 hydroxy 3 methylglutaryl coenzyme A synthase antibody
    • 3-hydroxy-3-methylglutaryl coenzyme A synthase antibody
    • HMCS2_HUMAN antibody
    • HMG CoA synthase antibody
    • HMG-CoA synthase antibody
    • HMGCS 2 antibody
    • HMGCS2 antibody
    • Hydroxymethylglutaryl CoA synthase antibody
    • Hydroxymethylglutaryl CoA synthase mitochondrial antibody
    • Hydroxymethylglutaryl-CoA synthase antibody
    • mitochondrial antibody
    see all

Anti-HMGCS2 antibody 画像

  • Anti-HMGCS2 antibody (ab104807) at 1.25 µg/ml + Human fetal liver lysate at 10 µg

    Predicted band size : 57 kDa

Anti-HMGCS2 antibody (ab104807) 使用論文

ab104807 has not yet been referenced specifically in any publications.

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Thank you for contacting us.
We have antibodies to HMG CoA Synthase (HMGS) 3 Hydroxy 3 Methyl Glutaryl CoA Synthase only. The catalogue numbers are ab14302; http://www.abcam.com/HMGCS2-antibody-ab14302.html
ab67242; http://www.abcam.com/HMGCS...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"