製品の概要

  • 製品名Anti-HLA Class II DRB3 antibody
  • 製品の詳細
    Rabbit polyclonal to HLA Class II DRB3
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Monkey
  • 免疫原

    Amino acids 4 - 260 of Human HLA Class II DRB3 (NP_072049).

  • ポジティブ・コントロール
    • A549 and HCT116 cell lysates

法規制情報

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • バッファーPreservative: 0.01% Thimerosal (merthiolate)
    Constituents: 10% Glycerol, 0.1M Tris, 0.1M Glycine, pH 7.0
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab98107 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/1000. Predicted molecular weight: 30 kDa.

ターゲット情報

  • 関連性HLA Class II DRB3 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB3 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.
  • 細胞内局在Cell membrane; Endoplasmic reticulum membrane; Golgi apparatus, trans-Golgi network membrane; Endosome membrane; Lysosome membrane; Late endosome membrane. Note: The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation.
  • 参照データベース
  • 別名
    • HLA class II histocompatibility antigen DR beta 3 chain antibody
    • HLA DR3B antibody
    • HLADR3B antibody
    • Major histocompatibility complex, class II DR beta 3 antibody

Anti-HLA Class II DRB3 antibody 画像

  • Anti-HLA Class II DRB3 antibody (ab98107) at 1/1000 dilution + A549 whole cell lysate at 30 µg

    Predicted band size : 30 kDa

Anti-HLA Class II DRB3 antibody (ab98107) 使用論文

ab98107 has not yet been referenced specifically in any publications.

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