FITC Anti-HLA A2 抗体 [BB7.2] (ab27728)
Key features and details
- FITC Mouse monoclonal [BB7.2] to HLA A2
- Suitable for: Flow Cyt
- Reacts with: Human
- Conjugation: FITC. Ex: 493nm, Em: 528nm
- Isotype: IgG2b
Related conjugates and formulations
製品の概要
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製品名
FITC Anti-HLA A2 antibody [BB7.2]
HLA A2 一次抗体 製品一覧 -
製品の詳細
FITC Mouse monoclonal [BB7.2] to HLA A2 -
由来種
Mouse -
標識
FITC. Ex: 493nm, Em: 528nm -
特異性
Ab27728 recognises the human HLA A2 histocompatability antigen. -
アプリケーション
適用あり: Flow Cytmore details -
種交差性
交差種: Human -
免疫原
Full length protein corresponding to Human HLA A2. Papain solubilized HLA-A2
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エピトープ
The epitope recognised by this antibody has been studied extensively and would appear to include the carboxy terminus of the alpha 2 helix and a turn on one of the underlying beta strands. -
特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C. -
バッファー
Preservative: 0.09% Sodium azide
Constituent: 1% BSA -
Concentration information loading...
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精製度
Protein G purified -
特記事項(精製)
Ab27728 was purified from tissue culture supernatant, and prepared by affinity chromatography. -
ポリ/モノ
モノクローナル -
クローン名
BB7.2 -
ミエローマ
NS1 -
アイソタイプ
IgG2b -
研究分野
関連製品
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Alternative Versions
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab27728の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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Flow Cyt |
1/10.
Use 10 µl of the suggested working dilution to label 106 cells or 100µl whole blood.
ab91368 - Mouse monoclonal IgG2b, is suitable for use as an isotype control with this antibody.
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特記事項 |
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Flow Cyt
1/10. Use 10 µl of the suggested working dilution to label 106 cells or 100µl whole blood.
ab91368 - Mouse monoclonal IgG2b, is suitable for use as an isotype control with this antibody.
|
ターゲット情報
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関連性
Involved in the presentation of foreign antigens to the immune system. Dimer of alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein. -
細胞内局在
Membrane; Single-pass type I membrane protein. -
参照データベース
- Entrez Gene: 3105 Human
- Omim: 142800 Human
- SwissProt: P04439 Human
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別名
- Antigen presenting molecule antibody
- HLA A antibody
- HLA A histocompatibility type antibody
see all
画像
データシートおよび資料
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Datasheet download
参考文献 (8)
ab27728 は 8 報の論文で使用されています。
- Viborg N et al. T cell recognition of novel shared breast cancer antigens is frequently observed in peripheral blood of breast cancer patients. Oncoimmunology 8:e1663107 (2019). PubMed: 31741759
- Li D et al. Engineering chimeric human and mouse major histocompatibility complex (MHC) class I tetramers for the production of T-cell receptor (TCR) mimic antibodies. PLoS One 12:e0176642 (2017). Flow Cyt . PubMed: 28448627
- Kim YH et al. Branched multipeptide immunotherapy for glioblastoma using human leukocyte antigen-A*0201-restricted cytotoxic T-lymphocyte epitopes from ERBB2, BIRC5 and CD99. Oncotarget 7:50535-50547 (2016). PubMed: 27409668
- Straetemans T et al. Recurrence of melanoma following T cell treatment: continued antigen expression in a tumor that evades T cell recruitment. Mol Ther 23:396-406 (2015). PubMed: 25363716
- Cheent KS et al. Synergistic inhibition of natural killer cells by the nonsignaling molecule CD94. Proc Natl Acad Sci U S A 110:16981-6 (2013). Human . PubMed: 24082146
- Whitfield-Larry F et al. HLA-A2-matched peripheral blood mononuclear cells from type 1 diabetic patients, but not nondiabetic donors, transfer insulitis to NOD-scid/?c(null)/HLA-A2 transgenic mice concurrent with the expansion of islet-specific CD8+ T cells. Diabetes 60:1726-33 (2011). Flow Cyt . PubMed: 21521873
- Hogan KT & Brown SL Localization and characterization of serologic epitopes on HLA-A2. Hum Immunol 33:185-92 (1992). PubMed: 1377666
- Parham P & Brodsky FM Partial purification and some properties of BB7.2. A cytotoxic monoclonal antibody with specificity for HLA-A2 and a variant of HLA-A28. Hum Immunol 3:277-99 (1981). PubMed: 7035415