製品の概要

製品の詳細

  • 由来
    Synthetic

特性

Our Abpromise guarantee covers the use of ab43147 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生理活性
    Immunoreactive with all sera of HIV-2 infected individuals.
  • アプリケーション

    ELISA

    Western blot

  • 製品の状態
    Liquid
  • 備考

    Immunoreactive with all sera of HIV-2 infected individuals.

  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: H2O

関連情報

  • 別名
    • Gp36
    • HIV 2
    • Human immunodeficiency virus 2
  • 関連性
    HIV2 infections at present, are predominantly found in west Africa where it is the dominant form of HIV. Both HIV1 and HIV2 have the same modes of transmission and are associated with similar opportunistic infections and AIDS. In persons infected with HIV2, immunodeficiency seems to develop more slowly and to be milder, but as the disease advances, HIV2 infectiousness seems to increase. Little is known about the best approach to the clinical treatment and care of patients infected with HIV2. Some drugs used to treat HIV1 are ineffective. HIV1 and HIV2 have similar gag (viral core) and pol (polymerase) regions, they have relatively dissimilar env (envelope) regions. Owing to this lack of homology in the envelope region, there is little serologic cross-reactivity of the antibodies directed against the envelope antigens of both HIV1 and HIV2. The env gp36 ectodomain is highly conserved and elicits a type-specific antibody response. Hence, most licensed diagnostic assays incorporate gp36-derived antigens to detect HIV2 specific antibodies. It is becoming important to differentiate between single infection with either HIV1 or HIV2 and dual infection.

参考文献

ab43147 has not yet been referenced specifically in any publications.

ab43147 を使用した論文を発表された方は、こちらまでお知らせください。データシートに掲載させていただきます。

レビューと Q&A

レビューを送る 質問を送る

2 reviews or Q&A

10
Votes: Highest First

It is not clear in the reply on immunoreaction with HIV positive sera.

Does it mean the pepetide doesn't react with only HIV1 positive sera, and shows positive reaction with HIV2 positive sera?

Or it does not react with both HIV1 ...

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Thank you for contacting us.

I received the following information from the lab to your questions:

1) Does it mean the peptide doesn't react with only HIV1 positivesera, and shows positive reaction with HIV2 positive sera?
Read More

1) number of residues (how long/large is peptide)?
2) what is the sequence homology of this peptide with HIV1 gp41?

Thank you for contacting us.

I received the following information from the lab:

The peptide contains 23 AA. It has no homology to HIV-1, and no immunoreaction with HIV positive sera.

I hope this information is helpful to ...

Read More

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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