Anti-HIV1 Nef 抗体 (ab63919)

製品の概要

• 製品名Anti-HIV1 Nef antibody
  HIV1 Nef 一次抗体 製品一覧
• 製品の詳細
  Guinea pig polyclonal to HIV1 Nef
• アプリケーション適用あり: WB, ELISAmore details
• 種交差性
  Reacts with HIV-1.
• 免疫原

  Recombinant Nef protein over-expressed in E. coli with a plasmid carrying the Nef coding region of HIV1 virus, subtype B.

• ポジティブ･コントロール
  • Extract of MT4 cells uninfected or infected with HIV1 (LAI strain).

製品の特性

• 製品の状態Liquid
• 保存方法Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
• バッファーPreservative: 0.09% Sodium Azide
  Constituents: Whole serum
• 精製度Whole antiserum
• 特記事項（精製）ab93919 is highly purified by several steps of chromatography.
• ポリ/モノポリクローナル
• アイソタイプIgG
• 研究分野
  • Microbiology
  • Organism
  • Virus
  • RNA Virus
  • ssRNA positive strand virus
  • HIV

  • Immunology
  • Immune System Diseases
  • Antiviral Signaling
  • HIV

アプリケーション

ターゲット情報

• 関連性Nef is a early protein that appears to play a role in optimizing the host cell environment for viral replication without causing cell death by apoptosis. Nef enhances virus infectivity and pathogenicity. It down modulates surface MHC I molecules and internalized molecules are sequested to the trans-Golgi network. The number of cell surface CD4 antigen are decreased by interacting with the Src family kinase LCK thereby inducing LCK CD4 dissociation and by increasing clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation.
• 別名
  • C terminal core protein antibody
  • F protein antibody
  • Nef antibody

  • Negative factor antibody
  • p27 antibody

  see all