Anti-Histone acetyltransferase MYST3 抗体 (ab110945)

製品の概要

  • 製品名Anti-Histone acetyltransferase MYST3 antibody
    Histone acetyltransferase MYST3 一次抗体 製品一覧
  • 製品の詳細
    Goat polyclonal to Histone acetyltransferase MYST3
  • アプリケーション適用あり: ELISA, IHC-Pmore details
    適用なし: WB
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide:

    C-EKIKDKEETELD

    , corresponding to internal sequence amino acids 1361-1372 of Human KAT6A/ HAT3 (NP_006757.2).

  • ポジティブ・コントロール
    • Human Adrenal tissue.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • バッファーpH: 7.30
    Preservative: 0.02% Sodium azide
    Constituents: Tris buffered saline, 0.5% BSA
  • Concentration information loading...
  • 精製度Protein G purified
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab110945 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ELISA 1/16000.
IHC-P Use a concentration of 3.75 µg/ml.
  • 追加情報Is unsuitable for WB.
  • ターゲット情報

    • 機能Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2.
    • 関連疾患Note=Chromosomal aberrations involving MYST3 may be a cause of acute myeloid leukemias. Translocation t(8;16)(p11;p13) with CREBBP; translocation t(8;22)(p11;q13) with EP300. MYST3-CREBBP may induce leukemia by inhibiting RUNX1-mediated transcription. Inversion inv(8)(p11;q13) generates the MYST3-NCOA2 oncogene, which consists of the N-terminus part of MYST3/MOZ and the C-terminus part of NCOA2/TIF2. MYST3-NCOA2 binds to CREBBP and disrupts its function in transcription activation.
      Note=A chromosomal aberration involving MYST3 is a cause of therapy-related myelodysplastic syndrome. Translocation t(2;8)(p23;p11.2) with ASXL2 generates a MYST3-ASXL2 fusion protein.
    • 配列類似性Belongs to the MYST (SAS/MOZ) family.
      Contains 1 C2HC-type zinc finger.
      Contains 1 H15 (linker histone H1/H5 globular) domain.
      Contains 2 PHD-type zinc fingers.
    • ドメインThe N-terminus is involved in transcriptional activation while the C-terminus is involved in transcriptional repression.
    • 翻訳後修飾Autoacetylated.
      Phosphorylated upon DNA damage, probably by ATM or ATR.
    • 細胞内局在Nucleus. Partially concentrated in subnuclear foci distinct from PML bodies, and excluded from the nucleoli.
    • Information by UniProt
    • 参照データベース
    • 別名
      • HAT 3 antibody
      • Histone acetyltransferase MYST3 antibody
      • Monocytic leukemia zinc finger protein antibody
      • MOZ antibody
      • MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3 antibody
      • MYST histone acetyltransferase (monocytic leukemia) 3 antibody
      • MYST protein 3 antibody
      • MYST-3 antibody
      • MYST3 antibody
      • MYST3_HUMAN antibody
      • OTTHUMP00000197392 antibody
      • OTTHUMP00000197394 antibody
      • OTTHUMP00000225722 antibody
      • Runt related transcription factor binding protein 2 antibody
      • Runt-related transcription factor-binding protein 2 antibody
      • RUNXBP2 antibody
      • SAS2 antibody
      • SAS2 and TIP60 protein 3 antibody
      • TIP60 protein 3 antibody
      • YBF2/SAS3 antibody
      • ZC2HC6A antibody
      • Zinc finger protein 220 antibody
      • ZNF220 antibody
      see all

    Anti-Histone acetyltransferase MYST3 antibody 画像

    • ab110945, at 3.75µg/ml, staining KAT6A / HAT3 in formalin-fixed, paraffin-embedded Human Adrenal tissue by Immunohistochemistry.

    Anti-Histone acetyltransferase MYST3 antibody (ab110945) 使用論文

    ab110945 has not yet been referenced specifically in any publications.

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