製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to HIRA
  • 特異性
    Detects endogenous levels of total HIRA protein
  • アプリケーション
    適用あり: IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse
  • 免疫原

    Synthetic peptide derived from an internal region of Human HIRA.

  • ポジティブ・コントロール
    • Human tonsil tissue.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab111196 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

ターゲット情報

  • 機能
    Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit.
  • 組織特異性
    Expressed at high levels in kidney, pancreas and skeletal muscle and at lower levels in brain, heart, liver, lung, and placenta.
  • 配列類似性
    Belongs to the WD repeat HIR1 family.
    Contains 8 WD repeats.
  • 発生段階
    Expressed during embryogenesis.
  • 翻訳後修飾
    Sumoylated.
    Phosphorylated by CDK2/CCNA1 and CDK2/CCNE1 on Thr-555 in vitro. Also phosphorylated on Thr-555 and Ser-687 in vivo.
  • 細胞内局在
    Nucleus. Nucleus > PML body. Primarily, though not exclusively, localized to the nucleus. Localizes to PML bodies immediately prior to onset of senescence.
  • Information by UniProt
  • 参照データベース
  • 別名
    • DGCR1 antibody
    • DiGeorge critical region gene 1 antibody
    • HIR antibody
    • HIR histone cell cycle regulation defective homolog A antibody
    • HIRA antibody
    • HIRA protein antibody
    • HIRA_HUMAN antibody
    • Histone cell cycle regulator antibody
    • Protein HIRA antibody
    • TUP 1 antibody
    • TUP1 like enhancer of split protein 1 antibody
    • TUP1-like enhancer of split protein 1 antibody
    • TUPLE1 antibody
    see all

画像

  • ab111196 at 1/50 dilution staining HIRA in paraffin-embedded Human Tonsil tissue by Immunohistochemistry. The image on the right is treated with the synthesized peptide.

プロトコール

参考文献

ab111196 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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