製品の概要

  • 製品名Anti-HIPPI antibody
    HIPPI 一次抗体 製品一覧
  • 製品の詳細
    Goat polyclonal to HIPPI
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Mouse, Human
    交差が予測される動物種: Rat, Cow, Xenopus laevis
  • 免疫原

    Synthetic peptide:

    C-EQPQEYDDPNA

    , corresponding to internal sequence amino acids 103-113 of human HIPPI (NP_060480.1).

  • ポジティブ・コントロール
    • Human and mouse brain lysates

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • バッファーPreservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, Tris buffered saline, pH 7.3
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • 特記事項(精製)ab87623 was purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab87623 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 - 3 µg/ml. Detects a band of approximately 49 kDa (predicted molecular weight: 49 kDa).

ターゲット情報

  • 機能Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear.
  • 組織特異性Present in many tissues such as brain, thymus, lymph node, lung, liver, skin and kidney (at protein level).
  • 配列類似性Belongs to the IFT57 family.
  • ドメインThe pseudo DED region (pDED) meadiates the interaction with HIP1.
  • 細胞内局在Cytoplasm > cytoskeleton > cilium basal body. Concentrates within the inner segment of cilia.
  • Information by UniProt
  • 参照データベース
  • 別名
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    • HIP1 interacting protein HIPPI antibody
    • Hip1 protein interactor antibody
    • HIP1-interacting protein antibody
    • HIPPI antibody
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    • Huntingtin interacting protein 1 protein interactor antibody
    • IFT 57 antibody
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Anti-HIPPI antibody 画像

  • Anti-HIPPI antibody (ab87623) at 1 µg/ml + mouse brain lysate (in RIPA buffer) at 35 µg

    Predicted band size : 49 kDa
    Observed band size : 49 kDa

Anti-HIPPI antibody (ab87623) 使用論文

ab87623 has not yet been referenced specifically in any publications.

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There are currently no Abreviews or Questions for ab87623.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"