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機能
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, in the presence or in the absence of BRCA1-BARD1 E3 ubiquitin-protein ligase complex, catalyzes the synthesis of 'Lys-48'-linked polyubiquitin chains. Does not transfer ubiquitin directly to but elongates monoubiquitinated substrate protein. Mediates the selective degradation of short-lived and abnormal proteins, such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. Ubiquitinates huntingtin. May mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53/TP53. Proposed to be involved in ubiquitination and proteolytic processing of NF-kappa-B; in vitro supports ubiquitination of NFKB1. In case of infection by cytomegaloviruses may be involved in the US11-dependent degradation of MHC class I heavy chains following their export from the ER to the cytosol. In case of viral infections may be involved in the HPV E7 protein-dependent degradation of RB1.
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組織特異性
Expressed in all tissues tested, including spleen, thymus, prostate, testis, ovary, small intestine, colon, peripheral blood leukocytes, T-lymphocytes, monocytes, granulocytes and bone marrow mononuclear cells. Highly expressed in brain, with highest levels found in cortex and striatum and at lower levels in cerebellum and brainstem.
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パスウェイ
Protein modification; protein ubiquitination.
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配列類似性
Belongs to the ubiquitin-conjugating enzyme family.
Contains 1 UBA domain.
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翻訳後修飾
Sumoylation at Lys-14 impairs catalytic activity.
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細胞内局在
Cytoplasm.
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Information by UniProt
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参照データベース
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別名
- E2 25K antibody
- E2(25K) antibody
- HIP-2 antibody
- Huntingtin interacting protein 2 antibody
- Huntingtin-interacting protein 2 antibody
- HYPG antibody
- LIG antibody
- UBC1 antibody
- UBE2K antibody
- UBE2K_HUMAN antibody
- Ubiquitin carrier protein antibody
- Ubiquitin conjugating enzyme E2 25 kDa antibody
- ubiquitin conjugating enzyme E2K antibody
- ubiquitin conjugating enzyme E2K (UBC1 homolog, yeast) antibody
- Ubiquitin protein ligase antibody
- Ubiquitin-conjugating enzyme E2 K antibody
- Ubiquitin-conjugating enzyme E2(25K) antibody
- Ubiquitin-conjugating enzyme E2-25 kDa antibody
- Ubiquitin-conjugating enzyme E2-25K antibody
- Ubiquitin-protein ligase antibody
see all