製品の概要

  • 製品名Anti-HIC5 antibody [4B2-D8]
    HIC5 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [4B2-D8] to HIC5
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Recombinant full length protein, corresponding to amino acids 1-445 of Human HIC5

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab57754 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
  • 追加情報WB: Use at a concentration of 1-5 µg/ml.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA-binding activity.
    • 組織特異性Expressed in platelets, smooth muscle and prostate stromal cells (at protein level).
    • 配列類似性Belongs to the paxillin family.
      Contains 4 LIM zinc-binding domains.
    • ドメインThe LIM zinc-binding domains mediate glucocorticoid receptor coactivation and interaction with AR, CRIP2, ILK, LIMS1, NR3C1, PPARG, TCF3, TCF7L2, SLC6A3 and SMAD3. The LIM zinc-binding 2 and LIM zinc-binding 3 domains mediate targeting to focal adhesions and actin stress fibers. The LIM zinc-binding 3 and LIM zinc-binding 4 domains mediate interaction with TRAF4 and MAPK15. The LIM zinc-binding 4 domain mediates interaction with HSPB1, homooligomerization and targeting to the nuclear matrix. The LIM zinc-binding 3 domain mediates interaction with PTPN12.
      The LD (leucine and aspartate-rich) motif 3 mediates interaction with GIT1 and functions as a nuclear export signal.
    • 翻訳後修飾Phosphorylated by gonadotropin-releasing hormone-activated SRC.
    • 細胞内局在Cell junction > focal adhesion. Nucleus matrix. Cytoplasm > cytoskeleton. Associated with the actin cytoskeleton; colocalizes with stress fibers.
    • Information by UniProt
    • 参照データベース
    • 別名
      • Androgen receptor coactivator 55 kDa protein antibody
      • Androgen receptor coactivator ARA55 antibody
      • Androgen receptor-associated protein of 55 kDa antibody
      • ARA55 antibody
      • Hic-5 antibody
      • Hydrogen peroxide-inducible clone 5 protein antibody
      • Tgfb1i1 antibody
      • TGFI1_HUMAN antibody
      • Transforming growth factor beta 1 induced transcript 1 antibody
      • Transforming growth factor beta-1-induced transcript 1 protein antibody
      • TSC 5 antibody
      see all

    Anti-HIC5 antibody [4B2-D8] 画像



    • Predicted band size : 48 kDa
      HIC5 antibody (ab57754) at 1ug/lane + HeLa cell lysate at 25ug/lane.

    Anti-HIC5 antibody [4B2-D8] (ab57754) 使用論文

    ab57754 has not yet been referenced specifically in any publications.

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