Anti-HHV8 抗体 [LN53] (ab4103)
Key features and details
- Rat monoclonal [LN53] to HHV8
- Suitable for: IHC-P, IHC-Fr
- Reacts with: Human herpesvirus 8
- Isotype: IgG2c
製品の概要
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製品名
Anti-HHV8 antibody [LN53]
HHV8 一次抗体 製品一覧 -
製品の詳細
Rat monoclonal [LN53] to HHV8 -
由来種
Rat -
特異性
HHV 8 is the likely etiological agent of Kaposi’s sarcoma (KS). HHV 8 encodes a latent nuclear antigen (LNA), which is the product of the viral gene orf 73. LNA is capable of forming a complex with retinoblastoma susceptibility gene product, which may be related to its oncogenic activity. -
アプリケーション
適用あり: IHC-P, IHC-Frmore details -
種交差性
交差種: Human herpesvirus 8 -
免疫原
Recombinant full length protein corresponding to HHV8. Corresponding to the latent nuclear antigen 1 molecule of HHV 8.
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エピトープ
Located within the ORF-73 region. -
ポジティブ・コントロール
- Kaposi’s sarcoma.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
バッファー
pH: 7.3
Preservative: 0.05% Sodium azide
Constituents: Tissue culture supernatant, 1% BSA -
Concentration information loading...
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精製度
IgG fraction -
ポリ/モノ
モノクローナル -
クローン名
LN53 -
アイソタイプ
IgG2c -
研究分野
関連製品
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Compatible Secondaries
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab4103の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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IHC-P |
1/25 - 1/50. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
ABC method. |
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IHC-Fr |
1/25 - 1/50.
ABC method. |
特記事項 |
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IHC-P
1/25 - 1/50. Perform heat mediated antigen retrieval before commencing with IHC staining protocol. ABC method. |
IHC-Fr
1/25 - 1/50. ABC method. |
ターゲット情報
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関連性
HHV8 has been found to be associated with three different diseases observed in AIDS patients; kaposi's sarcoma, primary effusion lymphoma (which is a rare type of non-Hodgkin lymphoma affecting the body cavities) and multicentric Castleman's disease. To date there is much evidence to support a direct role for HHV8 in kaposi's sarcoma. -
別名
- HHV 8 antibody
- Human Herpes Virus 8 antibody
- Human herpesvirus 8 antibody
see all
プロトコール
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (14)
ab4103 は 14 報の論文で使用されています。
- Vladimirova O et al. Phase separation and DAXX redistribution contribute to LANA nuclear body and KSHV genome dynamics during latency and reactivation. PLoS Pathog 17:e1009231 (2021). PubMed: 33471863
- Chen Q et al. Kaposi's sarcoma herpesvirus is associated with osteosarcoma in Xinjiang populations. Proc Natl Acad Sci U S A 118:N/A (2021). PubMed: 33674386
- Ju E et al. Reversible switching of primary cells between normal and malignant state by oncogenic virus KSHV and CRISPR/Cas9-mediated targeting of a major viral latent protein. J Med Virol 93:5065-5075 (2021). PubMed: 33942339
- Chen W et al. Kaposi's sarcoma-associated herpesvirus vFLIP promotes MEndT to generate hybrid M/E state for tumorigenesis. PLoS Pathog 17:e1009600 (2021). PubMed: 34936683
- Méndez-Solís O et al. Kaposi's sarcoma herpesvirus activates the hypoxia response to usurp HIF2α-dependent translation initiation for replication and oncogenesis. Cell Rep 37:110144 (2021). PubMed: 34965440