製品の概要

  • 製品名Anti-hHR23A antibody
    hHR23A 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to hHR23A
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region within N terminal amino acids 41-70 of Human hHR23A (NP_005044.1).

  • ポジティブ・コントロール
    • HeLa cell line lysates.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
  • バッファーPreservative: 0.09% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • 特記事項(精製)ab123311 is purified through a protein A column, followed by peptide affinity purification.
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab123311 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/100 - 1/500. Predicted molecular weight: 40 kDa.

ターゲット情報

  • 機能Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome.
    Involved in nucleotide excision repair and is thought to be functional equivalent for RAD23B in global genome nucleotide excision repair (GG-NER) by association with XPC. In vitro, the XPC:RAD23A dimer has NER activity. Can stabilize XPC.
    Involved in vpr-dependent replication of HIV-1 in non-proliferating cells and primary macrophages. Required for the association of HIV-1 vpr with the host proteasome.
  • 配列類似性Belongs to the RAD23 family.
    Contains 2 UBA domains.
    Contains 1 ubiquitin-like domain.
  • ドメインThe ubiquitin-like domain mediates interaction with ATXN3.
    The ubiquitin-like (UBL) and the UBA (ubiquitin-associated) domains interact intramolecularly in a highly dynamic manner, as each UBA domain competes for an overlapping UBL domain surface. Binding of ubiquitin or proteasome subunit PSMD4 disrupt the UBL-UBA domain interactions and drive RAD23A in to an open conformation.
  • 翻訳後修飾Phosphorylated upon DNA damage, probably by ATM or ATR.
  • 細胞内局在Nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • hHR 23A antibody
    • hHR23A antibody
    • HR23A antibody
    • MGC111083 antibody
    • RAD 23a antibody
    • RAD23 homolog A (S. cerevisiae) antibody
    • RAD23 homolog A antibody
    • RAD23 yeast homolog A antibody
    • RAD23A antibody
    • RD23A_HUMAN antibody
    • UV excision repair protein RAD23 antibody
    • UV excision repair protein RAD23 homolog A antibody
    see all

Anti-hHR23A antibody 画像

  • Anti-hHR23A antibody (ab123311) at 1/100 dilution + HeLa cell line lysates at 35 µg

    Predicted band size : 40 kDa

Anti-hHR23A antibody (ab123311) 使用論文

ab123311 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab123311.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"