ab78259 is partially purified rabbit serum. Antibodies reactive with the Type I isozyme were present in the original antiserum; these were removed by affinity chromatography on a column of immobilized Type I isozyme, and the affinity-depleted serum restored to original volume.
Predominant hexokinase isozyme expressed in insulin-responsive tissues such as skeletal muscle.
Carbohydrate metabolism; hexose metabolism.
Belongs to the hexokinase family. Contains 2 hexokinase domains.
The N- and C-terminal halves of this hexokinase show extensive sequence similarity to each other. The catalytic activity is associated with the C-terminus while regulatory function is associated with the N-terminus. Each domain can bind a single glucose and Gluc-6-P molecule.
Mitochondrion outer membrane. Its hydrophobic N-terminal sequence may be involved in membrane binding.
Waskova-Arnostova P et al. Chronic hypoxia enhances expression and activity of mitochondrial creatine kinase and hexokinase in the rat ventricular myocardium. Cell Physiol Biochem33:310-20 (2014).
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