製品の概要

  • 製品名Anti-HEXB antibody
    HEXB 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to HEXB
  • アプリケーション適用あり: WB, IHC-P, ELISAmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide derived from the C-terminal of human HEXB.

  • ポジティブ・コントロール
    • Colon carcinoma tissue. Jurkat cells.

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab65001 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
IHC-P
ELISA
  • 追加情報ELISA: 1/20000.
    IHC-P: 1/50 - 1/100. Perform heat mediated antigen retrieval via the pressure cooker method, boiling for 2-3 min, before commencing with IHC staining protocol.
    WB: 1/500 - 1/1000. Detects a band of approximately 63 kDa (predicted molecular weight: 63 kDa).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues.
    • 関連疾患Defects in HEXB are the cause of GM2-gangliosidosis type 2 (GM2G2) [MIM:268800]; also known as Sandhoff disease. GM2-gangliosidosis is an autosomal recessive lysosomal storage disease marked by the accumulation of GM2 gangliosides in the neuronal cells. GM2G2 is clinically indistinguishable from GM2-gangliosidosis type 1, presenting startle reactions, early blindness, progressive motor and mental deterioration, macrocephaly and cherry-red spots on the macula.
    • 配列類似性Belongs to the glycosyl hydrolase 20 family.
    • 翻訳後修飾N-linked glycans at Asn-142 and Asn-190 consist of Man(3)-GlcNAc(2) and Man(5 to 7)-GlcNAc(2), respectively.
      The beta-A and beta-B chains are produced by proteolytic processing of the precursor beta chain.
    • 細胞内局在Lysosome.
    • Information by UniProt
    • 参照データベース
    • 別名
      • Beta hexosaminidase beta chain antibody
      • Beta hexosaminidase subunit beta antibody
      • Beta N acetylhexosaminidase antibody
      • Beta-hexosaminidase subunit beta chain A antibody
      • Beta-N-acetylhexosaminidase subunit beta antibody
      • Cervical cancer proto oncogene 7 protein antibody
      • Cervical cancer proto-oncogene 7 protein antibody
      • ENC 1AS antibody
      • Epididymis luminal protein 248 antibody
      • HCC 7 antibody
      • HCC-7 antibody
      • HCC7 antibody
      • HEL 248 antibody
      • HEX B antibody
      • Hexb antibody
      • HEXB_HUMAN antibody
      • Hexosaminidase B (beta polypeptide) antibody
      • Hexosaminidase B antibody
      • Hexosaminidase subunit B antibody
      • HexosaminidaseB antibody
      • N acetyl beta glucosaminidase antibody
      • N-acetyl-beta-glucosaminidase subunit beta antibody
      see all

    Anti-HEXB antibody 画像

    • Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue using HEXB antibody (ab65001) at 1/50 dilution, in the presence (right panel) and absence (left panel) of immunising peptide. Antigen retrieval was performed by boiling in a pressure cooker for 2-3 min. A Polymer system was used for signal enhancing. Stained using DAB.
    • All lanes : Anti-HEXB antibody (ab65001) at 1/500 dilution

      Lane 1 : Extracts from Jurkat cells
      Lane 2 : Extracts from Jurkat cells with immunizing peptide at 5 µg

      Lysates/proteins at 10 µg per lane.


      Predicted band size : 63 kDa
      Observed band size : 63 kDa

    Anti-HEXB antibody (ab65001) 使用論文

    ab65001 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab65001.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"