製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to HEXA
  • アプリケーション
    適用あり: WB, ELISAmore details
  • 種交差性
    交差種: Human
  • 免疫原

    KLH conjugated synthetic peptide selected from the central region of Human HEXA (NP_000511.2).

  • ポジティブ・コントロール
    • HepG2 cell line lysates

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab93111 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
ELISA
  • 追加情報
    ELISA: 1/1000.
    WB: 1/100 - 1/500. Predicted molecular weight: 61 kDa.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能
      Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues. The form B is active against certain oligosaccharides. The form S has no measurable activity.
    • 関連疾患
      Defects in HEXA are the cause of GM2-gangliosidosis type 1 (GM2G1) [MIM:272800]; also known as Tay-Sachs disease. GM2-gangliosidosis is an autosomal recessive lysosomal storage disease marked by the accumulation of GM2 gangliosides in the neuronal cells. GM2G1 is characterized by GM2 gangliosides accumulation in the absence of HEXA activity, leading to neurodegeneration and, in the infantile form, death in early childhood. GM2G1 has an increased incidence among Ashkenazi Jews and French Canadians in eastern Quebec. It exists in several forms: infantile (most common and most severe), juvenile and adult (late onset).
    • 配列類似性
      Belongs to the glycosyl hydrolase 20 family.
    • 翻訳後修飾
      N-linked glycan at Asn-115 consists of Man(3)-GlcNAc(2).
    • 細胞内局在
      Lysosome.
    • Information by UniProt
    • 参照データベース
    • 別名
      • Beta hexosaminidase alpha chain precursor antibody
      • Beta hexosaminidase subunit alpha antibody
      • Beta N acetylhexosaminidase antibody
      • Beta N acetylhexosaminidase subunit alpha antibody
      • Beta-hexosaminidase A antibody
      • Beta-hexosaminidase subunit alpha antibody
      • Beta-N-acetylhexosaminidase subunit alpha antibody
      • Hexa antibody
      • HEXA_HUMAN antibody
      • Hexosaminidase A (alpha polypeptide) antibody
      • Hexosaminidase A alpha polypeptide antibody
      • Hexosaminidase A antibody
      • Hexosaminidase subunit A antibody
      • MGC99608 antibody
      • N acetyl beta glucosaminidase antibody
      • N acetyl beta glucosaminidase subunit alpha antibody
      • N-acetyl-beta-glucosaminidase subunit alpha antibody
      • TSD antibody
      see all

    画像

    • Anti-HEXA antibody (ab93111) at 1/100 dilution + HepG2 cell line lysates at 35 µg

      Predicted band size : 61 kDa

    プロトコール

    参考文献

    ab93111 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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