製品の概要

  • 製品名Anti-HES7 antibody
    HES7 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to HES7
  • アプリケーション適用あり: WB, IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Cow, Dog
  • 免疫原

    Synthetic peptide derived from a region between residues 62-112 of human HES7.

    .

  • ポジティブ・コントロール
    • Fetal human heart lysate, Human kidney and human pancreas tissue.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab26062 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 25 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.
IHC-P Use at an assay dependent concentration.

ターゲット情報

  • 機能Transcriptional repressor. Represses transcription from both N box- and E box-containing promoters. May with HES1, cooperatively regulate somite formation in the presomitic mesoderm (PSM). May function as a segmentation clock, which is essential for coordinated somite segmentation.
  • 関連疾患Defects in HES7 are the cause of spondylocostal dysostosis type 4 (SCDO4) [MIM:613686]. A rare condition of variable severity characterized by vertebral and costal anomalies. The main feature include dwarfism, vertebral fusion, hemivertebrae, posterior rib fusion, reduced rib number, and other rib malformations.
  • 配列類似性Contains 1 basic helix-loop-helix (bHLH) domain.
    Contains 1 Orange domain.
  • ドメインHas a particular type of basic domain which includes a helix-interrupting proline.
    The C-terminal WRPW motif is a transcriptional repression motif which is necessary for interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins.
  • 細胞内局在Nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • bHLH factor Hes7 antibody
    • bHLHb37 antibody
    • Class B basic helix loop helix protein 37 antibody
    • Class B basic helix-loop-helix protein 37 antibody
    • Hairy and enhancer of split 7 antibody
    • hes family bHLH transcription factor 7 antibody
    • Hes7 antibody
    • HES7_HUMAN antibody
    • hHes7 antibody
    • SCDO4 antibody
    • Transcription factor HES 7 antibody
    • Transcription factor HES-7 antibody
    see all

Anti-HES7 antibody 画像

  • Anti-HES7 antibody (ab26062) at 1 µg/ml (in 5% skim milk / PBS buffer) + fetal human heart lysate

    Secondary
    HRP conjugated anti-Rabbit IgG

    Predicted band size : 25 kDa
    Observed band size : 25,26 kDa (why is the actual band size different from the predicted?)
  • Immunohistochemical detection of HES7 using 4 ug/ml ab26062 in paraffin embedded human kidney tissue section. Arrows indicate positively labelled epithelial cells of the renal tubule.
  • Immunohistochemical detection of HES7 using 4 ug/ml ab26062 in paraffin embedded human pancreas tissue section. Arrows indicate positively labelled epithelial cells of the pancreatic acinus.

Anti-HES7 antibody (ab26062) 使用論文

ab26062 has not yet been referenced specifically in any publications.

Product Wall

Thank you for your inquiry.

According to the SwissProt home page (http://www.uniprot.org/uniprot/Q9BYE0) there is only one isoform.

Since I ma not experienced in the field of Transcription factor HES-7 I can only confirm that if bot...

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Thank you for your inquiry.

The exact immunogen sequences for these two antibodies are proprietary information. All the information I can provide is the region as it is stated on the datasheets:

ab26062: The immunogen is within ther...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"