HES6 is a transcription cofactor that iteself does not bind to DNA but suppresses both HES1-mediated N box-dependent transcriptional repression and binding of HES1 to E box sequences. It also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/MASH1 and TCFEA2/E47, allowing ASCL1 and TCFEA2 to upregulate transcription in its presence.
HES6 appears to have novel functions in tumour and cancer cell lines, although these have not yet been elucidated fully.
Methot L et al. Interaction and Antagonistic Roles of NF-?B and Hes6 in the Regulation of Cortical Neurogenesis. Mol Cell Biol33:2797-808 (2013).
Read more (PubMed: 23689134) »
Haapa-Paananen S et al. HES6 gene is selectively overexpressed in glioma and represents an important transcriptional regulator of glioma proliferation. Oncogene : (2011).
Read more (PubMed: 21785461) »