製品の概要

  • 製品名Anti-HERV antibody
    HERV 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to HERV
  • アプリケーション適用あり: WBmore details
  • 免疫原

    Synthetic peptide:

    QRPGNIDAP

    , corresponding to amino acids 42-50 of Human Endogenous Retrovirus (HERV).

  • ポジティブ・コントロール
    • Human placenta lysate.
  • 特記事項


    Reacts with a replication competent Human Endogenous Retrovirus (HERVW) isolated from placenta. The synthetic peptide sequence used as immunogen is taken from the virus envelope polyprotein sequence. Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. The HERVW endogenous envelope protein has retained its original fusogenic properties and participates in trophoblast fusion during placenta morphogenesis.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • バッファーPreservative: 0.02% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • 一次抗体 備考Reacts with a replication competent Human Endogenous Retrovirus (HERVW) isolated from placenta. The synthetic peptide sequence used as immunogen is taken from the virus envelope polyprotein sequence. Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. The HERVW endogenous envelope protein has retained its original fusogenic properties and participates in trophoblast fusion during placenta morphogenesis.
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab45500 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/250 - 1/1000. Detects a band of approximately 56 kDa.

ターゲット情報

  • 機能Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has retained its original fusogenic properties and participates in trophoblast fusion during placenta morphogenesis.
    SU mediates receptor recognition. This interaction triggers the refolding of the transmembrane protein (TM) and is thought to activate its fusogenic potential by unmasking its fusion peptide (By similarity). Seems to recognize the type D mammalian retrovirus receptors SLC1A4 and SLC1A5, as it induces fusion of cells expressing these receptors in vitro.
    The transmembrane protein (TM) acts as a class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of membranes.
  • 組織特異性Expressed at higher level in placental syncytiotrophoblast. Expressed at intermediate level in testis. Seems also to be found at low level in adrenal tissue, bone marrow, breast, colon, kidney, ovary, prostate, skin, spleen, thymus, thyroid, brain and trachea. Both mRNA and protein levels are significantly increased in the brain of individuals with multiple sclerosis, particularly in astrocytes and microglia.
  • 配列類似性Belongs to the gamma type-C retroviral envelope protein family. HERV class-I W env subfamily.
  • 発生段階In placenta, detected at higher level during early pregnancy and at lower level during late pregnancy.
  • ドメインThe cytoplasmic region is essential for the fusiogenic function.
    The 17 amino acids long immunosuppressive region is present in many retroviral envelope proteins. Synthetic peptides derived from this relatively conserved sequence inhibit immune function in vitro and in vivo.
  • 翻訳後修飾Specific enzymatic cleavages in vivo yield mature proteins. Envelope glycoproteins are synthesized as a inactive precursor that is heavily N-glycosylated and processed likely by furin in the Golgi to yield the mature SU and TM proteins. The cleavage site between SU and TM requires the minimal sequence [KR]-X-[KR]-R. The intracytoplasmic tail cleavage by the viral protease that is required for the fusiogenic activity of some retroviruses envelope proteins seems to have been lost during evolution.
    The CXXC motif is highly conserved across a broad range of retroviral envelope proteins. It is thought to participate in the formation of a labile disulfide bond possibly with the CX6CC motif present in the transmembrane protein. Isomerization of the intersubunit disulfide bond to an SU intrachain disulfide bond is thought to occur upon receptor recognition in order to allow membrane fusion.
  • 細胞内局在Cell membrane; Virion and Cell membrane. The surface protein is not anchored to the membrane, but localizes to the extracellular surface through its binding to TM.
  • Information by UniProt
  • 別名
    • Endogenous retrovirus group W member 1 antibody
    • env antibody
    • Env-W antibody
    • Envelope polyprotein gPr73 antibody
    • Enverin antibody
    • ENW1_HUMAN antibody
    • ERVW antibody
    • ERVW-1 antibody
    • Gp24 antibody
    • Gp50 antibody
    • HERV-7q Envelope protein antibody
    • HERV-W envelope protein antibody
    • HERVW antibody
    • SU antibody
    • Syncytin 1 antibody
    • Syncytin antibody
    • Syncytin-1 antibody
    • TM antibody
    • Transmembrane protein antibody
    see all

Anti-HERV antibody 画像

Anti-HERV antibody (ab45500) 使用論文

ab45500 has not yet been referenced specifically in any publications.

Product Wall

Thank you for your enquiry. I am sorry to confirm that because we carry over 70,000 products, it is not feasible for us to keep small sample sizes of our products to send to customers. We are happy to reassure our customers that all of our prod...

Read More

Thank you for your call today. We do not currently sell antibodies against EMV, gag, capsid or HMTV. I have passed this information onto our new products team so please keep an eye on our catalgue as we may add them in the future. We do provide prim...

Read More

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"