This fast track antibody is not yet fully characterized. It is subject to these terms and conditions

製品の概要

  • 製品名Anti-HERV antibody
    HERV 一次抗体 製品一覧
  • 製品の詳細
    Goat polyclonal to HERV

    This product is a fast track antibody. It has been affinity purified and shows high titre values against the immunizing peptide by ELISA. Read the terms of use »

  • 特異性Preliminary experiments gave an approx 30kDa band in Human Placenta lysates after 1µg/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 67.9kDa according to NP_001007254.2. The 30kDa band was successfully blocked by incubation with the immunizing peptide. We would appreciate any feedback from people in the field - have any results been reported with other antibodies/lysates? Have any further splice variants/modified forms been reported?
  • 種交差性

    交差が予測される動物種: Human, Chimpanzee
  • 免疫原

    Synthetic peptide:

    C-PQDNFTLTASS

    , corresponding to internal sequence amino acids 313-323 of Human HERV (NP_001007254.2)

  • ポジティブ・コントロール
    • Human Placenta lysates

製品の特性

ターゲット情報

  • 機能Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has retained its original fusogenic properties and participates in trophoblast fusion during placenta morphogenesis.
    SU mediates receptor recognition. This interaction triggers the refolding of the transmembrane protein (TM) and is thought to activate its fusogenic potential by unmasking its fusion peptide (By similarity). Seems to recognize the type D mammalian retrovirus receptors SLC1A4 and SLC1A5, as it induces fusion of cells expressing these receptors in vitro.
    The transmembrane protein (TM) acts as a class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of membranes.
  • 組織特異性Expressed at higher level in placental syncytiotrophoblast. Expressed at intermediate level in testis. Seems also to be found at low level in adrenal tissue, bone marrow, breast, colon, kidney, ovary, prostate, skin, spleen, thymus, thyroid, brain and trachea. Both mRNA and protein levels are significantly increased in the brain of individuals with multiple sclerosis, particularly in astrocytes and microglia.
  • 配列類似性Belongs to the gamma type-C retroviral envelope protein family. HERV class-I W env subfamily.
  • 発生段階In placenta, detected at higher level during early pregnancy and at lower level during late pregnancy.
  • ドメインThe cytoplasmic region is essential for the fusiogenic function.
    The 17 amino acids long immunosuppressive region is present in many retroviral envelope proteins. Synthetic peptides derived from this relatively conserved sequence inhibit immune function in vitro and in vivo.
  • 翻訳後修飾Specific enzymatic cleavages in vivo yield mature proteins. Envelope glycoproteins are synthesized as a inactive precursor that is heavily N-glycosylated and processed likely by furin in the Golgi to yield the mature SU and TM proteins. The cleavage site between SU and TM requires the minimal sequence [KR]-X-[KR]-R. The intracytoplasmic tail cleavage by the viral protease that is required for the fusiogenic activity of some retroviruses envelope proteins seems to have been lost during evolution.
    The CXXC motif is highly conserved across a broad range of retroviral envelope proteins. It is thought to participate in the formation of a labile disulfide bond possibly with the CX6CC motif present in the transmembrane protein. Isomerization of the intersubunit disulfide bond to an SU intrachain disulfide bond is thought to occur upon receptor recognition in order to allow membrane fusion.
  • 細胞内局在Cell membrane; Virion and Cell membrane. The surface protein is not anchored to the membrane, but localizes to the extracellular surface through its binding to TM.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Endogenous retrovirus group W member 1 antibody
    • env antibody
    • Env-W antibody
    • Envelope polyprotein gPr73 antibody
    • Enverin antibody
    • ENW1_HUMAN antibody
    • ERVW antibody
    • ERVW-1 antibody
    • Gp24 antibody
    • Gp50 antibody
    • HERV-7q Envelope protein antibody
    • HERV-W envelope protein antibody
    • HERVW antibody
    • SU antibody
    • Syncytin 1 antibody
    • Syncytin antibody
    • Syncytin-1 antibody
    • TM antibody
    • Transmembrane protein antibody
    see all

Anti-HERV antibody (ab111173) 使用論文

ab111173 has not yet been referenced specifically in any publications.

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Thank you for your enquiry. I am sorry to confirm that because we carry over 70,000 products, it is not feasible for us to keep small sample sizes of our products to send to customers. We are happy to reassure our customers that all of our prod...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"