Anti-Hepatitis C Virus Core Antigen 抗体 [11-B3] (ab18929)


  • 製品名Anti-Hepatitis C Virus Core Antigen antibody [11-B3]
    Hepatitis C Virus Core Antigen 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [11-B3] to Hepatitis C Virus Core Antigen
  • アプリケーション適用あり: IHC-Fr, ELISA, WBmore details
  • 種交差性
    HCV core antigen.
  • 免疫原

    Recombinant full length HCV core from 1B strain.

  • エピトープAmino acids 70-90.
  • 特記事項Mouse monoclonal [11-B3] to Hepatitis C Virus Core Antigen (ab18929) stains primarily cytoplasmic; mainly in the perinuclear area.



Our Abpromise guarantee covers the use of ab18929 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-Fr 1/20.
ELISA Use at an assay dependent concentration.
WB 1/1000.


  • 関連性The hepatitis C virus (HCV) core protein represents the first 191 amino acids of the viral precursor polyprotein and is cotranslationally inserted into the membrane of the endoplasmic reticulum. Hepatitis C virus (HCV) core is a viral structural protein; it also participates in some cellular processes, including transcriptional regulation. However the mechanisms of core-mediated transcriptional regulation remain poorly understood. Hepatitis C virus (HCV) core protein is thought to contribute to HCV pathogenesis through its interaction with various signal transduction pathways. In addition, HCV core antigen is a recently developed marker of hepatitis C infection. The HCV core protein has been previously shown to circulate in the bloodstream of HCV-infected patients and inhibit host immunity through an interaction with gC1qR. Hepatitis C Virus is a positive, single stranded RNA virus in the Flaviviridae family. The genome is approximately 10,000 nucleotides and encodes a single polyprotein of about 3,000 amino acids. The polyprotein is processed by host cell and viral proteases into three major structural proteins and several non structural proteins necessary for viral replication. Hepatitis C virus (HCV) causes most cases of non-A, non-B hepatitis and results in most HCV infected people developing chronic infections, liver cirrhosis and hepatocellular carcinoma. T cell responses, including interferon-gamma production are severely suppressed in chronic HCV patients.
  • 細胞内局在Endoplasmic reticulum
  • 別名
    • Core protein p21 antibody
    • HCV core antigen antibody
    • HCV core protein antibody
    • Hepatitis C Virus core protein antibody

Anti-Hepatitis C Virus Core Antigen antibody [11-B3] (ab18929) 使用論文

ab18929 has not yet been referenced specifically in any publications.

Product Wall

Abcam guarantees this product to work in the species/application used in this Abreview.
Application Western blot
Sample Human Cell lysate - whole cell (hepatoma cell lline)
Gel Running Conditions Reduced Denaturing (12)
Loading amount 50 µg
Treatment transfection of HCV core plasmid
Specification hepatoma cell lline
Blocking step BSA as blocking agent for 1 hour(s) and 30 minute(s) · Concentration: 5% · Temperature: RT°C

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投稿 May 16 2016