製品の概要

  • 製品名
    Anti-Heparin Cofactor II antibody
    Heparin Cofactor II 一次抗体 製品一覧
  • 製品の詳細
    Sheep polyclonal to Heparin Cofactor II
  • アプリケーション
    適用あり: WB, ELISAmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Full length native purified Human Heparin Cofactor II

製品の特性

  • 製品の状態
    Liquid
  • 保存方法
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • バッファー
    Preservative: None
    Constituents: 50% Glycerol, Water
  • Concentration information loading...
  • 精製度
    Ion Exchange Chromatography
  • 特記事項(精製)
    Salt fractionation followed by ion exchange chromatography
  • ポリ/モノ
    ポリクローナル
  • アイソタイプ
    IgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab61371 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use at an assay dependent concentration. Predicted molecular weight: 57 kDa.
ELISA Use at an assay dependent dilution.

ターゲット情報

  • 機能
    Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III). Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner.
    Peptides at the N-terminal of HC-II have chemotactic activity for both monocytes and neutrophils.
  • 組織特異性
    Expressed predominantly in liver. Also present in plasma.
  • 関連疾患
    Thrombophilia due to heparin cofactor 2 deficiency
  • 配列類似性
    Belongs to the serpin family.
  • ドメイン
    The N-terminal acidic repeat region mediates, in part, the glycosaminoglycan-accelerated thrombin inhibition.
  • 翻訳後修飾
    Phosphorylation sites are present in the extracellular medium.
  • Information by UniProt
  • 参照データベース
  • 別名
    • D22S673 antibody
    • HC II antibody
    • HC-II antibody
    • HC2 antibody
    • HCF2 antibody
    • HEP2_HUMAN antibody
    • Heparin cofactor 2 antibody
    • Heparin cofactor II antibody
    • HLS2 antibody
    • Leuserpin 2 antibody
    • LS2 antibody
    • Protease inhibitor leuserpin 2 antibody
    • Protease inhibitor leuserpin-2 antibody
    • serine (or cysteine) proteinase inhibitor, clade D (heparin cofactor), member 1 antibody
    • Serpin D1 antibody
    • serpin peptidase inhibitor, clade D (heparin cofactor), member 1 antibody
    • SERPIND1 antibody
    • THPH10 antibody
    see all

プロトコール

参考文献

ab61371 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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