The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use at an assay dependent concentration. Predicted molecular weight: 57 kDa.
Use at an assay dependent dilution.
機能Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III). Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner. Peptides at the N-terminal of HC-II have chemotactic activity for both monocytes and neutrophils.
組織特異性Expressed predominantly in liver. Also present in plasma.
関連疾患Thrombophilia due to heparin cofactor 2 deficiency
配列類似性Belongs to the serpin family.
ドメインThe N-terminal acidic repeat region mediates, in part, the glycosaminoglycan-accelerated thrombin inhibition.
翻訳後修飾Phosphorylation sites are present in the extracellular medium.