The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/2000. Predicted molecular weight: 57 kDa.
Use at an assay dependent dilution.
機能Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III). Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner. Peptides at the N-terminal of HC-II have chemotactic activity for both monocytes and neutrophils.
組織特異性Expressed predominantly in liver. Also present in plasma.
関連疾患Thrombophilia due to heparin cofactor 2 deficiency
配列類似性Belongs to the serpin family.
ドメインThe N-terminal acidic repeat region mediates, in part, the glycosaminoglycan-accelerated thrombin inhibition.
翻訳後修飾Phosphorylation sites are present in the extracellular medium.
Anti-Heparin Cofactor II antibody [74E5] (ab51051) 使用論文
This product has been referenced in:
Acosta-Martin AE et al. Quantitative mass spectrometry analysis using PAcIFIC for the identification of plasma diagnostic biomarkers for abdominal aortic aneurysm. PLoS One6:e28698 (2011).
Read more (PubMed: 22163325) »