Anti-Hemoglobin 抗体 [Haem1] (ab401)

製品の概要

  • 製品名Anti-Hemoglobin antibody [Haem1]
    Hemoglobin 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [Haem1] to Hemoglobin
  • 特異性hHb - 100% hAlbumin - <0.01% hHaptoglobin - 0.4% hMyoglobin - <0.03% hTransferrin - <0.01% Cross-reactivity values have been calculated on weight/weight basis. They can vary because of the presence of antigen or related impurities in protein preparations used for cross reactivity assays. Affinity constant: 1x1010 l/mol human haemoglobin.
  • アプリケーション適用あり: RIA, ELISAmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Full length native protein (purified) (Human).

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab401 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
RIA Use at an assay dependent dilution.
ELISA Use at an assay dependent dilution.

ターゲット情報

  • 機能Involved in oxygen transport from the lung to the various peripheral tissues.
  • 組織特異性Red blood cells.
  • 関連疾患Defects in HBA1/HBA2 may be a cause of Heinz body anemias (HEIBAN) [MIM:140700]. This is a form of non-spherocytic hemolytic anemia of Dacie type 1. After splenectomy, which has little benefit, basophilic inclusions called Heinz bodies are demonstrable in the erythrocytes. Before splenectomy, diffuse or punctate basophilia may be evident. Most of these cases are probably instances of hemoglobinopathy. The hemoglobin demonstrates heat lability. Heinz bodies are observed also with the Ivemark syndrome (asplenia with cardiovascular anomalies) and with glutathione peroxidase deficiency.
    Defects in HBA1/HBA2 are the cause of alpha-thalassemia (A-THAL) [MIM:604131]. The thalassemias are the most common monogenic diseases and occur mostly in Mediterranean and Southeast Asian populations. The hallmark of alpha-thalassemia is an imbalance in globin-chain production in the adult HbA molecule. The level of alpha chain production can range from none to very nearly normal levels. Deletion of both copies of each of the two alpha-globin genes causes alpha(0)-thalassemia, also known as homozygous alpha thalassemia. Due to the complete absence of alpha chains, the predominant fetal hemoglobin is a tetramer of gamma-chains (Bart hemoglobin) that has essentially no oxygen carrying capacity. This causes oxygen starvation in the fetal tissues leading to prenatal lethality or early neonatal death. The loss of three alpha genes results in high levels of a tetramer of four beta chains (hemoglobin H), causing a severe and life-threatening anemia known as hemoglobin H disease. Untreated, most patients die in childhood or early adolescence. The loss of two alpha genes results in mild alpha-thalassemia, also known as heterozygous alpha-thalassemia. Affected individuals have small red cells and a mild anemia (microcytosis). If three of the four alpha-globin genes are functional, individuals are completely asymptomatic. Some rare forms of alpha-thalassemia are due to point mutations (non-deletional alpha-thalassemia). The thalassemic phenotype is due to unstable globin alpha chains that are rapidly catabolized prior to formation of the alpha-beta heterotetramers.
    Note=Alpha(0)-thalassemia is associated with non-immune hydrops fetalis, a generalized edema of the fetus with fluid accumulation in the body cavities due to non-immune causes. Non-immune hydrops fetalis is not a diagnosis in itself but a symptom, a feature of many genetic disorders, and the end-stage of a wide variety of disorders.
  • 配列類似性Belongs to the globin family.
  • 翻訳後修飾The initiator Met is not cleaved in variant Thionville and is acetylated.
  • Information by UniProt
  • 参照データベース
  • 別名
    • 3-prime alpha-globin gene antibody
    • Alpha 2 globin chain antibody
    • Alpha globin antibody
    • alpha one globin antibody
    • alpha-1 globin antibody
    • Alpha-globin antibody
    • Beta globin antibody
    • CD113t C antibody
    • CD31 antibody
    • Delta globin antibody
    • Erythremia, beta-globin type, included antibody
    • Gamma 1 globin antibody
    • Hb F Agamma antibody
    • HBA 1 antibody
    • HBA 2 antibody
    • HBA antibody
    • HBA T3 antibody
    • HBA-T2 antibody
    • HBA_HUMAN antibody
    • HBA1 antibody
    • HBA2 antibody
    • HBB antibody
    • Hbb-y antibody
    • HBD antibody
    • Hbe1 antibody
    • HBG 1 antibody
    • HBG antibody
    • HBG1 antibody
    • HBGA antibody
    • HBGR antibody
    • HBH antibody
    • Hemoglobin alpha 1 antibody
    • hemoglobin alpha 1 globin chain antibody
    • Hemoglobin alpha chain antibody
    • Hemoglobin alpha locus antibody
    • Hemoglobin alpha locus 1 antibody
    • hemoglobin alpha-1 chain antibody
    • Hemoglobin beta antibody
    • Hemoglobin beta chain antibody
    • Hemoglobin beta chain complex antibody
    • Hemoglobin beta locus antibody
    • Hemoglobin gamma 1 chain antibody
    • Hemoglobin gamma A antibody
    • Hemoglobin gamma A chain antibody
    • Hemoglobin gamma antibody
    • Hemoglobin subunit alpha antibody
    • Hemoglobin subunit beta antibody
    • Hemoglobin subunit gamma 1 antibody
    • hemoglobin, gamma, regulator of antibody
    • Hemoglobin--gamma locus, 136 alanaine antibody
    • HSGGL1 antibody
    • LVV-hemorphin-7 antibody
    • Methemoglobinemia, beta-globin type, included antibody
    • MGC126895 antibody
    • MGC126897 antibody
    • Minor alpha-globin locus antibody
    • PRO2979 antibody
    see all

Anti-Hemoglobin antibody [Haem1] (ab401) 使用論文

ab401 has not yet been referenced specifically in any publications.

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Thank you for contacting us.

The positive control ab77858 http://www.abcam.com/Hemoglobin-protein-ab77858.html should work with ab401.

Please be advised we have not used these products together. Our assumption is only based on the ...

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Thank you for contacting us.

We do not have rabbit antibody in catalogue we however have mouse monoclonal anti Hemoglobin antibody; the catalogue number is ab401; http://www.abcam.com/Hemoglobin-antibody-Haem1-ab401.html

This antibo...

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Thank you for your patience in waiting for a response regarding ab401 and ab402. The source of these antibodies returned my email today and stated that in all likelihood antibodies ab401 and ab402 to human Hemoglobin do not recognize fetal Hb. They ha...

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Regarding both ab401 and ab402, the epitope has not been identified, but is thought to be in the beta chain. To our knowledge, these antibodies have yet to be tested in Western blotting. All tested applications are specified on Abcam product datasheets...

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We stock a number of ELISA kits, but do not currently stock an anti-human hemoglobin ELISA kit.

We believe that antibodies to this modified version of hemoglobin are not commercially available.

The epitope has not been identified for this antibody, but is thought to be in the beta chain.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"