Anti-Hemoglobin A1c 抗体 [M0501129] (ab33847)

製品の概要

  • 製品名
    Anti-Hemoglobin A1c antibody [M0501129]
    Hemoglobin A1c 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [M0501129] to Hemoglobin A1c
  • 特異性
    The antibody recognizes human Hemoglobin A1c (the diabetic glycated hemoglobin marker),and all variants of A1c and S1c (the sickle cell glycated hemoglobin marker). The clone number has been updated from (8.F.127A) to (M0501129) both clone numbers name the same antibody clone.
  • アプリケーション
    適用あり: ELISAmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Hemoglobin A1c, N-terminal of the beta chain

  • 特記事項

    Abcam is committed to meeting high standards of ethical manufacturing and as such, we will be discontinuing this product, which has been generated by the ascites method, within the next year. We are sorry for any inconvenience this may cause. If you would like help finding an alternative product, please do not hesitate to contact our scientific support team.

製品の特性

  • 製品の状態
    Liquid
  • 保存方法
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Add glycerol to a final volume of 50% for extra stability and aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • バッファー
    Preservative: 0.05% Sodium Azide
    Constituents: Tris buffered saline, pH 7.2
  • Concentration information loading...
  • 精製度
    Protein A purified
  • ポリ/モノ
    モノクローナル
  • クローン名
    M0501129
  • アイソタイプ
    IgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab33847 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ELISA Use at an assay dependent dilution.

ターゲット情報

  • 機能
    Involved in oxygen transport from the lung to the various peripheral tissues.
    LVV-hemorphin-7 potentiates the activity of bradykinin, causing a decrease in blood pressure.
    Spinorphin: functions as an endogenous inhibitor of enkephalin-degrading enzymes such as DPP3, and as a selective antagonist of the P2RX3 receptor which is involved in pain signaling, these properties implicate it as a regulator of pain and inflammation.
  • 組織特異性
    Red blood cells.
  • 関連疾患
    Heinz body anemias
    Beta-thalassemia
    Sickle cell anemia
    Beta-thalassemia, dominant, inclusion body type
  • 配列類似性
    Belongs to the globin family.
  • 翻訳後修飾
    Glucose reacts non-enzymatically with the N-terminus of the beta chain to form a stable ketoamine linkage. This takes place slowly and continuously throughout the 120-day life span of the red blood cell. The rate of glycation is increased in patients with diabetes mellitus.
    S-nitrosylated; a nitric oxide group is first bound to Fe(2+) and then transferred to Cys-94 to allow capture of O(2).
    Acetylated on Lys-60, Lys-83 and Lys-145 upon aspirin exposure. PubMed:16916647 reports the identification of HBB acetylated on Lys-145 in the cytosolic fraction of HeLa cells. This may have resulted from contamination of the sample.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Beta-globin antibody
    • HBB antibody
    • HBB_HUMAN antibody
    • Hemoglobin beta chain antibody
    • Spinorphin antibody
    see all

Anti-Hemoglobin A1c antibody [M0501129] (ab33847) 使用論文

ab33847 has not yet been referenced specifically in any publications.

Product Wall

Thank you for your enquiries. Ab33847: This Ab is specific for Human hemoglobin A1C (the diabetic glycated hemoglobin marker); and also recognizes hemoglobin S1C (the sickle cell glycated hemoglobin marker). It does not recognize hemoglobin A. ...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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