製品の概要

製品の詳細

  • 由来Synthetic

関連製品

特性

Our Abpromise guarantee covers the use of ab41711 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Blocking - Blocking peptide for Anti-HDAC9 antibody (ab18970)

    Western blot

  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: 0.02% Sodium Azide
    Constituents: 0.1% BSA, PBS, pH 7.2

関連情報

  • 別名
    • HD 7
    • HD 7B
    • HD 9
    • HD7
    • HD7B
    • HD9
    • HDAC
    • HDAC 7
    • HDAC 7B
    • HDAC 9
    • HDAC 9B
    • HDAC 9FL
    • HDAC7
    • HDAC7B
    • HDAC9
    • HDAC9_HUMAN
    • HDAC9B
    • HDAC9FL
    • HDRP
    • Histone deacetylase 4/5 related protein
    • Histone deacetylase 7
    • Histone deacetylase 7B
    • Histone deacetylase 9
    • Histone deacetylase 9A
    • Histone deacetylase related protein
    • Histone deacetylase-related protein
    • KIAA0744
    • MEF2 interacting transcription repressor MITR
    • MEF2 interacting transcription repressor protein
    • MEF2-interacting transcription repressor MITR
    • MITR
    see all
  • 機能Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription.
    Isoform 3 lacks active site residues and therefore is catalytically inactive. Represses MEF2-dependent transcription by recruiting HDAC1 and/or HDAC3. Seems to inhibit skeletal myogenesis and to be involved in heart development. Protects neurons from apoptosis, both by inhibiting JUN phosphorylation by MAPK10 and by repressing JUN transcription via HDAC1 recruitment to JUN promoter.
  • 組織特異性Broadly expressed, with highest levels in brain, heart, muscle and testis. Isoform 3 is present in human bladder carcinoma cells (at protein level).
  • 関連疾患Note=A chromosomal aberration involving HDAC9 is found in a family with Peters anomaly. Translocation t(1;7)(q41;p21) with TGFB2 resulting in lack of HDAC9 protein.
  • 配列類似性Belongs to the histone deacetylase family. HD type 2 subfamily.
  • 翻訳後修飾Phosphorylated on Ser-220 and Ser-450; which promotes 14-3-3-binding, impairs interaction with MEF2, and antagonizes antimyogenic activity. Phosphorylated on Ser-240; which impairs nuclear accumulation (By similarity). Isoform 7 is phosphorylated on Tyr-1010. Phosphorylated by the PKC kinases PKN1 and PKN2, impairing nuclear import.
    Sumoylated.
  • 細胞内局在Nucleus.
  • Information by UniProt

HDAC9 peptide (ab41711) 使用論文

ab41711 has not yet been referenced specifically in any publications.

Product Wall

I'd suggest trying to use the peptide in excess and incubating the peptide longer with the antibody as well as increasing the incubation volume.

Thank you for contacting us.

Blocking will be inefficient if you are mixing the antibody and peptide after first diluting to the working solutions. The better approach is to mix the peptide and antibody stock solutions, then dilute to the wo...

Read More

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"